Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
90 cases with simple somatic mutation data · 90 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TERT |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 54 |
| 90 |
| 60% |
| cbioportal |
| 2 | TP53 | Ssm | 45 | 90 | 50% | cbioportal |
| 3 | CTNNB1 | Ssm | 35 | 90 | 38.9% | cbioportal |
| 4 | TSC2 | Ssm | 26 | 90 | 28.9% | cbioportal |
| 28 | ALB | Ssm | 2 | 7 | 28.6% | cbioportal |
| 5 | ARID1A | Ssm | 20 | 90 | 22.2% | cbioportal |
| 103 | SETDB1 | Ssm | 1 | 7 | 14.3% | cbioportal |
| 9 | AXIN1 | Ssm | 5 | 37 | 13.5% | cbioportal |
| 15 | CDKN1A | Ssm | 4 | 37 | 10.8% | cbioportal |
| 6 | PIK3CA | Ssm | 9 | 90 | 10% | cbioportal |
| 7 | APC | Ssm | 8 | 90 | 8.9% | cbioportal |
| 23 | KMT2D | Ssm | 3 | 37 | 8.1% | cbioportal |
| 25 | PTPRD | Ssm | 3 | 37 | 8.1% | cbioportal |
| 8 | NF1 | Ssm | 7 | 90 | 7.8% | cbioportal |
| 42 | KMT2B | Ssm | 2 | 27 | 7.4% | cbioportal |
| 39 | H3-4 | Ssm | 2 | 35 | 5.7% | cbioportal |
| 54 | ZFHX3 | Ssm | 2 | 35 | 5.7% | cbioportal |
| 48 | PPM1D | Ssm | 2 | 35 | 5.7% | cbioportal |
| 55 | ZRSR2 | Ssm | 2 | 35 | 5.7% | cbioportal |
| 34 | EPHA7 | Ssm | 2 | 35 | 5.7% | cbioportal |
| 11 | NFE2L2 | Ssm | 5 | 90 | 5.6% | cbioportal |
| 10 | KDM6A | Ssm | 5 | 90 | 5.6% | cbioportal |
| 12 | PAK5 | Ssm | 5 | 90 | 5.6% | cbioportal |
| 40 | INPP4B | Ssm | 2 | 37 | 5.4% | cbioportal |
| 32 | CDK12 | Ssm | 2 | 37 | 5.4% | cbioportal |
| 31 | BAP1 | Ssm | 2 | 37 | 5.4% | cbioportal |
| 18 | RB1 | Ssm | 4 | 90 | 4.4% | cbioportal |
| 14 | BRCA1 | Ssm | 4 | 90 | 4.4% | cbioportal |
| 17 | PTCH1 | Ssm | 4 | 90 | 4.4% | cbioportal |
| 16 | DNMT3A | Ssm | 4 | 90 | 4.4% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07