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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
426 cases with simple somatic mutation data · 446 cases total · 2026-02-19 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | VHL |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 218 |
| 426 |
| 51.2% |
| cbioportal |
| 2 | PBRM1 | Ssm | 145 | 426 | 34% | cbioportal |
| 3 | MUC4 | Ssm | 90 | 426 | 21.1% | cbioportal |
| 4 | TTN | Ssm | 63 | 426 | 14.8% | cbioportal |
| 5 | SETD2 | Ssm | 55 | 426 | 12.9% | cbioportal |
| 6 | BAP1 | Ssm | 42 | 426 | 9.9% | cbioportal |
| 7 | MUC16 | Ssm | 34 | 426 | 8% | cbioportal |
| 8 | KDM5C | Ssm | 29 | 426 | 6.8% | cbioportal |
| 9 | MTOR | Ssm | 23 | 426 | 5.4% | cbioportal |
| 10 | PABPC1 | Ssm | 19 | 426 | 4.5% | cbioportal |
| 11 | HMCN1 | Ssm | 18 | 426 | 4.2% | cbioportal |
| 14 | PTEN | Ssm | 17 | 426 | 4% | cbioportal |
| 15 | USH2A | Ssm | 17 | 426 | 4% | cbioportal |
| 12 | AHNAK2 | Ssm | 17 | 426 | 4% | cbioportal |
| 13 | KMT2C | Ssm | 17 | 426 | 4% | cbioportal |
| 16 | MACF1 | Ssm | 16 | 426 | 3.8% | cbioportal |
| 17 | MAGEC1 | Ssm | 16 | 426 | 3.8% | cbioportal |
| 18 | ADGRV1 | Ssm | 15 | 426 | 3.5% | cbioportal |
| 19 | DNAH9 | Ssm | 15 | 426 | 3.5% | cbioportal |
| 22 | SYNE1 | Ssm | 15 | 426 | 3.5% | cbioportal |
| 21 | PCLO | Ssm | 15 | 426 | 3.5% | cbioportal |
| 20 | LRP1B | Ssm | 15 | 426 | 3.5% | cbioportal |
| 25 | DST | Ssm | 14 | 426 | 3.3% | cbioportal |
| 24 | ATM | Ssm | 14 | 426 | 3.3% | cbioportal |
| 26 | KMT2D | Ssm | 14 | 426 | 3.3% | cbioportal |
| 23 | ARID1A | Ssm | 14 | 426 | 3.3% | cbioportal |
| 30 | MUC2 | Ssm | 13 | 426 | 3.1% | cbioportal |
| 31 | NEB | Ssm | 13 | 426 | 3.1% | cbioportal |
| 29 | MUC17 | Ssm | 13 | 426 | 3.1% | cbioportal |
| 27 | FBN2 | Ssm | 13 | 426 | 3.1% | cbioportal |
Data updated 21 days agoSource updated 2026-02-19