Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
812 cases with simple somatic mutation data · 1,122 cases total · 2026-01-07 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | IDH1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 411 |
| 812 |
| 50.6% |
| cbioportal |
| 2 | TP53 | Ssm | 322 | 812 | 39.7% | cbioportal |
| 3 | ATRX | Ssm | 208 | 812 | 25.6% | cbioportal |
| 4 | TTN | Ssm | 109 | 812 | 13.4% | cbioportal |
| 5 | PTEN | Ssm | 108 | 812 | 13.3% | cbioportal |
| 6 | EGFR | Ssm | 87 | 812 | 10.7% | cbioportal |
| 7 | CIC | Ssm | 79 | 812 | 9.7% | cbioportal |
| 8 | MUC16 | Ssm | 69 | 812 | 8.5% | cbioportal |
| 9 | PIK3CA | Ssm | 63 | 812 | 7.8% | cbioportal |
| 10 | NF1 | Ssm | 53 | 812 | 6.5% | cbioportal |
| 11 | RYR2 | Ssm | 46 | 812 | 5.7% | cbioportal |
| 12 | PIK3R1 | Ssm | 45 | 812 | 5.5% | cbioportal |
| 13 | FUBP1 | Ssm | 44 | 812 | 5.4% | cbioportal |
| 14 | FLG | Ssm | 38 | 812 | 4.7% | cbioportal |
| 15 | PCLO | Ssm | 33 | 812 | 4.1% | cbioportal |
| 16 | HMCN1 | Ssm | 31 | 812 | 3.8% | cbioportal |
| 17 | NOTCH1 | Ssm | 28 | 812 | 3.4% | cbioportal |
| 18 | PKHD1 | Ssm | 28 | 812 | 3.4% | cbioportal |
| 19 | SPTA1 | Ssm | 27 | 812 | 3.3% | cbioportal |
| 21 | RB1 | Ssm | 26 | 812 | 3.2% | cbioportal |
| 20 | LRP2 | Ssm | 26 | 812 | 3.2% | cbioportal |
| 24 | OBSCN | Ssm | 22 | 812 | 2.7% | cbioportal |
| 23 | KEL | Ssm | 22 | 812 | 2.7% | cbioportal |
| 22 | AHNAK2 | Ssm | 22 | 812 | 2.7% | cbioportal |
| 26 | SYNE1 | Ssm | 22 | 812 | 2.7% | cbioportal |
| 25 | SMARCA4 | Ssm | 22 | 812 | 2.7% | cbioportal |
| 27 | DNAH5 | Ssm | 21 | 812 | 2.6% | cbioportal |
| 28 | FRAS1 | Ssm | 21 | 812 | 2.6% | cbioportal |
| 29 | MUC17 | Ssm | 21 | 812 | 2.6% | cbioportal |
| 32 | FAT2 | Ssm | 20 | 812 | 2.5% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07