Hepatocellular Carcinoma

Hepatocellular Carcinoma · CancerIndex

Data completeness5 / 7 dimensions

Epidemiology (no data yet)
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Genomics (data present)
Evidence (data present)
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Definition

What this entity is

A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation.

Definition text as published by ncit-evs Curated

Data updated 22 days agoSource updated 26.08e

Taxonomy

Position in the hierarchies

Several hierarchies coexist; edges are listed per hierarchy type with their source.

Parents

ncit

Digestive System AdenocarcinomaSubtype
Liver CarcinomaSubtype

Children (23)

ncit

Anatomy

Hepatocellular Carcinoma

What this entity is

Position in the hierarchies

Anatomical sites

Synonyms (15)

At a glance