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CI-CAN-00000003Explore in graph →
Non-malignant20,485 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
151 cases with simple somatic mutation data · 151 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 106 |
| 151 |
| 70.2% |
| cbioportal |
| 2 | TTN | Ssm | 81 | 151 | 53.6% | cbioportal |
| 3 | MUC16 | Ssm | 41 | 151 | 27.2% | cbioportal |
| 4 | SYNE1 | Ssm | 36 | 151 | 23.8% | cbioportal |
| 5 | LRP1B | Ssm | 34 | 151 | 22.5% | cbioportal |
| 6 | FLG | Ssm | 33 | 151 | 21.9% | cbioportal |
| 7 | SPTA1 | Ssm | 32 | 151 | 21.2% | cbioportal |
| 8 | PCLO | Ssm | 31 | 151 | 20.5% | cbioportal |
| 9 | CSMD3 | Ssm | 26 | 151 | 17.2% | cbioportal |
| 11 | PCDH15 | Ssm | 24 | 151 | 15.9% | cbioportal |
| 10 | FAT3 | Ssm | 24 | 151 | 15.9% | cbioportal |
| 12 | CNTN6 | Ssm | 22 | 151 | 14.6% | cbioportal |
| 14 | PTPRD | Ssm | 22 | 151 | 14.6% | cbioportal |
| 13 | CSMD1 | Ssm | 22 | 151 | 14.6% | cbioportal |
| 16 | HMCN1 | Ssm | 21 | 151 | 13.9% | cbioportal |
| 17 | LAMA1 | Ssm | 21 | 151 | 13.9% | cbioportal |
| 15 | FAT4 | Ssm | 21 | 151 | 13.9% | cbioportal |
| 18 | USH2A | Ssm | 21 | 151 | 13.9% | cbioportal |
| 19 | APOB | Ssm | 20 | 151 | 13.2% | cbioportal |
| 20 | CDKN2A | Ssm | 20 | 151 | 13.2% | cbioportal |
| 21 | ZNF804B | Ssm | 19 | 151 | 12.6% | cbioportal |
| 24 | RIMS2 | Ssm | 18 | 151 | 11.9% | cbioportal |
| 23 | PCDH17 | Ssm | 18 | 151 | 11.9% | cbioportal |
| 25 | RYR2 | Ssm | 18 | 151 | 11.9% | cbioportal |
| 26 | ZFHX4 | Ssm | 18 | 151 | 11.9% | cbioportal |
| 22 | DOCK2 | Ssm | 18 | 151 | 11.9% | cbioportal |
| 27 | CUBN | Ssm | 16 | 151 | 10.6% | cbioportal |
| 28 | RYR3 | Ssm | 16 | 151 | 10.6% | cbioportal |
| 33 | PTPRT | Ssm | 15 | 151 | 9.9% | cbioportal |
| 30 | ERBB4 | Ssm | 15 | 151 | 9.9% | cbioportal |
Data updated 22 days agoSource updated 2026-01-07