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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
106 cases with simple somatic mutation data · 106 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | VHL |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 43 |
| 106 |
| 40.6% |
| cbioportal |
| 2 | PBRM1 | Ssm | 31 | 106 | 29.2% | cbioportal |
| 3 | TTN | Ssm | 21 | 106 | 19.8% | cbioportal |
| 4 | MUC16 | Ssm | 15 | 106 | 14.2% | cbioportal |
| 5 | SETD2 | Ssm | 12 | 106 | 11.3% | cbioportal |
| 6 | BAP1 | Ssm | 9 | 106 | 8.5% | cbioportal |
| 7 | CSMD3 | Ssm | 8 | 106 | 7.5% | cbioportal |
| 8 | AHNAK2 | Ssm | 7 | 106 | 6.6% | cbioportal |
| 10 | HMCN1 | Ssm | 6 | 106 | 5.7% | cbioportal |
| 14 | TET2 | Ssm | 6 | 106 | 5.7% | cbioportal |
| 11 | KMT2C | Ssm | 6 | 106 | 5.7% | cbioportal |
| 9 | FRYL | Ssm | 6 | 106 | 5.7% | cbioportal |
| 12 | MTOR | Ssm | 6 | 106 | 5.7% | cbioportal |
| 13 | MUC4 | Ssm | 6 | 106 | 5.7% | cbioportal |
| 20 | ZNF536 | Ssm | 5 | 106 | 4.7% | cbioportal |
| 18 | PIK3CA | Ssm | 5 | 106 | 4.7% | cbioportal |
| 19 | PKHD1 | Ssm | 5 | 106 | 4.7% | cbioportal |
| 16 | KCNMA1 | Ssm | 5 | 106 | 4.7% | cbioportal |
| 15 | ELOC | Ssm | 5 | 106 | 4.7% | cbioportal |
| 17 | KEAP1 | Ssm | 5 | 106 | 4.7% | cbioportal |
| 31 | KAT2A | Ssm | 4 | 106 | 3.8% | cbioportal |
| 32 | KDM5C | Ssm | 4 | 106 | 3.8% | cbioportal |
| 53 | ZNF831 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 43 | SPG11 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 42 | SLC4A3 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 33 | KRT32 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 41 | RYR2 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 40 | RANBP2 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 39 | PKHD1L1 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 24 | CUBN | Ssm | 4 | 106 | 3.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-05