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CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
469 cases with simple somatic mutation data · 473 cases total · 2026-01-13 · mapped to Cutaneous Melanoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TTN | Ssm | 337 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 469 |
| 71.9% |
| cbioportal |
| 2 | MUC16 | Ssm | 311 | 469 | 66.3% | cbioportal |
| 3 | BRAF | Ssm | 235 | 469 | 50.1% | cbioportal |
| 4 | DNAH5 | Ssm | 231 | 469 | 49.3% | cbioportal |
| 5 | PCLO | Ssm | 209 | 469 | 44.6% | cbioportal |
| 6 | LRP1B | Ssm | 182 | 469 | 38.8% | cbioportal |
| 7 | ADGRV1 | Ssm | 166 | 469 | 35.4% | cbioportal |
| 8 | ANK3 | Ssm | 158 | 469 | 33.7% | cbioportal |
| 9 | CSMD1 | Ssm | 156 | 469 | 33.3% | cbioportal |
| 10 | DNAH7 | Ssm | 156 | 469 | 33.3% | cbioportal |
| 11 | MGAM | Ssm | 152 | 469 | 32.4% | cbioportal |
| 12 | PKHD1L1 | Ssm | 151 | 469 | 32.2% | cbioportal |
| 14 | XIRP2 | Ssm | 151 | 469 | 32.2% | cbioportal |
| 13 | RP1 | Ssm | 151 | 469 | 32.2% | cbioportal |
| 15 | HYDIN | Ssm | 149 | 469 | 31.8% | cbioportal |
| 16 | FAT4 | Ssm | 148 | 469 | 31.6% | cbioportal |
| 18 | DSCAM | Ssm | 145 | 469 | 30.9% | cbioportal |
| 17 | APOB | Ssm | 145 | 469 | 30.9% | cbioportal |
| 19 | FLG | Ssm | 143 | 469 | 30.5% | cbioportal |
| 20 | DNAH8 | Ssm | 142 | 469 | 30.3% | cbioportal |
| 22 | USH2A | Ssm | 141 | 469 | 30.1% | cbioportal |
| 21 | CSMD3 | Ssm | 141 | 469 | 30.1% | cbioportal |
| 24 | THSD7B | Ssm | 139 | 469 | 29.6% | cbioportal |
| 23 | MUC17 | Ssm | 139 | 469 | 29.6% | cbioportal |
| 25 | CSMD2 | Ssm | 138 | 469 | 29.4% | cbioportal |
| 26 | FAT3 | Ssm | 138 | 469 | 29.4% | cbioportal |
| 27 | DNAH9 | Ssm | 137 | 469 | 29.2% | cbioportal |
| 28 | DNAH3 | Ssm | 130 | 469 | 27.7% | cbioportal |
| 29 | MXRA5 | Ssm | 129 | 469 | 27.5% | cbioportal |
| 30 | SPHKAP | Ssm | 128 | 469 | 27.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13