Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
817 cases with simple somatic mutation data · 818 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PIK3CA |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 282 |
| 817 |
| 34.5% |
| cbioportal |
| 2 | TP53 | Ssm | 280 | 817 | 34.3% | cbioportal |
| 3 | TTN | Ssm | 135 | 817 | 16.5% | cbioportal |
| 4 | CDH1 | Ssm | 107 | 817 | 13.1% | cbioportal |
| 5 | GATA3 | Ssm | 96 | 817 | 11.8% | cbioportal |
| 6 | MUC16 | Ssm | 71 | 817 | 8.7% | cbioportal |
| 7 | MAP3K1 | Ssm | 69 | 817 | 8.4% | cbioportal |
| 8 | KMT2C | Ssm | 62 | 817 | 7.6% | cbioportal |
| 9 | MUC4 | Ssm | 50 | 817 | 6.1% | cbioportal |
| 10 | MUC12 | Ssm | 47 | 817 | 5.8% | cbioportal |
| 11 | PTEN | Ssm | 42 | 817 | 5.1% | cbioportal |
| 13 | NCOA3 | Ssm | 41 | 817 | 5% | cbioportal |
| 14 | SYNE1 | Ssm | 41 | 817 | 5% | cbioportal |
| 12 | FLG | Ssm | 41 | 817 | 5% | cbioportal |
| 15 | NCOR1 | Ssm | 38 | 817 | 4.7% | cbioportal |
| 16 | USH2A | Ssm | 38 | 817 | 4.7% | cbioportal |
| 17 | NEB | Ssm | 37 | 817 | 4.5% | cbioportal |
| 18 | RYR2 | Ssm | 36 | 817 | 4.4% | cbioportal |
| 19 | ARID1A | Ssm | 33 | 817 | 4% | cbioportal |
| 20 | DMD | Ssm | 33 | 817 | 4% | cbioportal |
| 21 | RYR3 | Ssm | 33 | 817 | 4% | cbioportal |
| 22 | MUC5B | Ssm | 32 | 817 | 3.9% | cbioportal |
| 23 | SPEN | Ssm | 32 | 817 | 3.9% | cbioportal |
| 24 | RUNX1 | Ssm | 31 | 817 | 3.8% | cbioportal |
| 26 | FOXA1 | Ssm | 30 | 817 | 3.7% | cbioportal |
| 27 | HMCN1 | Ssm | 30 | 817 | 3.7% | cbioportal |
| 30 | SPTA1 | Ssm | 30 | 817 | 3.7% | cbioportal |
| 28 | LRP2 | Ssm | 30 | 817 | 3.7% | cbioportal |
| 25 | FAT3 | Ssm | 30 | 817 | 3.7% | cbioportal |
| 29 | MAP2K4 | Ssm | 30 | 817 | 3.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-05