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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
604 cases with simple somatic mutation data · 604 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KRAS |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 230 |
| 604 |
| 38.1% |
| cbioportal |
| 2 | TP53 | Ssm | 219 | 604 | 36.3% | cbioportal |
| 3 | EGFR | Ssm | 182 | 604 | 30.1% | cbioportal |
| 4 | RBM10 | Ssm | 97 | 604 | 16.1% | cbioportal |
| 5 | STK11 | Ssm | 90 | 604 | 14.9% | cbioportal |
| 6 | KEAP1 | Ssm | 68 | 604 | 11.3% | cbioportal |
| 7 | NF1 | Ssm | 48 | 604 | 7.9% | cbioportal |
| 10 | PTPRT | Ssm | 47 | 604 | 7.8% | cbioportal |
| 9 | PTPRD | Ssm | 47 | 604 | 7.8% | cbioportal |
| 8 | FAT1 | Ssm | 47 | 604 | 7.8% | cbioportal |
| 11 | ATM | Ssm | 44 | 604 | 7.3% | cbioportal |
| 12 | SETD2 | Ssm | 43 | 604 | 7.1% | cbioportal |
| 13 | BRAF | Ssm | 41 | 604 | 6.8% | cbioportal |
| 14 | MED12 | Ssm | 39 | 604 | 6.5% | cbioportal |
| 15 | EPHA3 | Ssm | 38 | 604 | 6.3% | cbioportal |
| 16 | PIK3CA | Ssm | 35 | 604 | 5.8% | cbioportal |
| 18 | NTRK3 | Ssm | 34 | 604 | 5.6% | cbioportal |
| 17 | MET | Ssm | 34 | 604 | 5.6% | cbioportal |
| 19 | MGA | Ssm | 33 | 596 | 5.5% | cbioportal |
| 20 | SMARCA4 | Ssm | 33 | 604 | 5.5% | cbioportal |
| 23 | EPHA5 | Ssm | 30 | 604 | 5% | cbioportal |
| 22 | ATRX | Ssm | 30 | 604 | 5% | cbioportal |
| 21 | ARID2 | Ssm | 30 | 604 | 5% | cbioportal |
| 24 | ERBB4 | Ssm | 29 | 604 | 4.8% | cbioportal |
| 25 | KMT2D | Ssm | 28 | 604 | 4.6% | cbioportal |
| 27 | ERBB2 | Ssm | 27 | 604 | 4.5% | cbioportal |
| 28 | GRIN2A | Ssm | 27 | 604 | 4.5% | cbioportal |
| 29 | TERT | Ssm | 27 | 604 | 4.5% | cbioportal |
| 26 | CDKN2A | Ssm | 27 | 604 | 4.5% | cbioportal |
| 31 | MTOR | Ssm | 26 | 604 | 4.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07