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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
3,323 cases with simple somatic mutation data · 3,323 cases total · 2026-01-08 · mapped to Myelodysplastic Syndrome EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TET2 | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 1,051 |
| 3,323 |
| 31.6% |
| cbioportal |
| 2 | ASXL1 | Ssm | 944 | 3,323 | 28.4% | cbioportal |
| 3 | SF3B1 | Ssm | 754 | 3,323 | 22.7% | cbioportal |
| 4 | SRSF2 | Ssm | 578 | 3,323 | 17.4% | cbioportal |
| 5 | DNMT3A | Ssm | 540 | 3,323 | 16.3% | cbioportal |
| 6 | RUNX1 | Ssm | 471 | 3,323 | 14.2% | cbioportal |
| 7 | TP53 | Ssm | 397 | 3,323 | 11.9% | cbioportal |
| 8 | STAG2 | Ssm | 312 | 3,323 | 9.4% | cbioportal |
| 9 | U2AF1 | Ssm | 289 | 3,323 | 8.7% | cbioportal |
| 10 | EZH2 | Ssm | 243 | 3,323 | 7.3% | cbioportal |
| 11 | KMT2D | Ssm | 224 | 3,323 | 6.7% | cbioportal |
| 12 | BCOR | Ssm | 220 | 3,323 | 6.6% | cbioportal |
| 13 | ZRSR2 | Ssm | 201 | 3,323 | 6% | cbioportal |
| 14 | CBL | Ssm | 200 | 3,323 | 6% | cbioportal |
| 15 | CUX1 | Ssm | 192 | 3,323 | 5.8% | cbioportal |
| 17 | SETBP1 | Ssm | 188 | 3,323 | 5.7% | cbioportal |
| 16 | NF1 | Ssm | 188 | 3,323 | 5.7% | cbioportal |
| 18 | IDH2 | Ssm | 180 | 3,323 | 5.4% | cbioportal |
| 19 | NRAS | Ssm | 179 | 3,323 | 5.4% | cbioportal |
| 20 | KMT2C | Ssm | 168 | 3,323 | 5.1% | cbioportal |
| 21 | SRCAP | Ssm | 153 | 3,323 | 4.6% | cbioportal |
| 22 | JAK2 | Ssm | 135 | 3,323 | 4.1% | cbioportal |
| 23 | NOTCH1 | Ssm | 135 | 3,323 | 4.1% | cbioportal |
| 24 | EP300 | Ssm | 132 | 3,323 | 4% | cbioportal |
| 25 | MGA | Ssm | 129 | 3,323 | 3.9% | cbioportal |
| 26 | KRAS | Ssm | 128 | 3,323 | 3.9% | cbioportal |
| 27 | DDX41 | Ssm | 125 | 3,323 | 3.8% | cbioportal |
| 28 | YLPM1 | Ssm | 121 | 3,323 | 3.6% | cbioportal |
| 29 | PHF6 | Ssm | 115 | 3,323 | 3.5% | cbioportal |
| 30 | KMT2A | Ssm | 113 | 3,323 | 3.4% | cbioportal |
Data updated 21 days agoSource updated 2026-01-08