Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
429 cases with simple somatic mutation data · 463 cases total · 2026-01-19 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC | Ssm | 308 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 429 |
| 71.8% |
| cbioportal |
| 2 | TP53 | Ssm | 237 | 429 | 55.2% | cbioportal |
| 3 | TTN | Ssm | 202 | 429 | 47.1% | cbioportal |
| 4 | KRAS | Ssm | 183 | 429 | 42.7% | cbioportal |
| 5 | PIK3CA | Ssm | 127 | 429 | 29.6% | cbioportal |
| 6 | SYNE1 | Ssm | 122 | 429 | 28.4% | cbioportal |
| 7 | MUC16 | Ssm | 121 | 429 | 28.2% | cbioportal |
| 8 | FAT4 | Ssm | 99 | 429 | 23.1% | cbioportal |
| 9 | RYR2 | Ssm | 86 | 429 | 20% | cbioportal |
| 10 | ZFHX4 | Ssm | 86 | 429 | 20% | cbioportal |
| 11 | OBSCN | Ssm | 84 | 429 | 19.6% | cbioportal |
| 12 | CSMD3 | Ssm | 80 | 429 | 18.6% | cbioportal |
| 13 | DNAH5 | Ssm | 80 | 429 | 18.6% | cbioportal |
| 14 | LRP1B | Ssm | 75 | 429 | 17.5% | cbioportal |
| 15 | PCLO | Ssm | 73 | 429 | 17% | cbioportal |
| 16 | RYR3 | Ssm | 71 | 429 | 16.6% | cbioportal |
| 17 | FBXW7 | Ssm | 70 | 429 | 16.3% | cbioportal |
| 18 | DNAH11 | Ssm | 69 | 429 | 16.1% | cbioportal |
| 19 | USH2A | Ssm | 69 | 429 | 16.1% | cbioportal |
| 20 | CSMD1 | Ssm | 67 | 429 | 15.6% | cbioportal |
| 21 | RYR1 | Ssm | 67 | 429 | 15.6% | cbioportal |
| 22 | ABCA13 | Ssm | 66 | 429 | 15.4% | cbioportal |
| 23 | ADGRV1 | Ssm | 65 | 429 | 15.2% | cbioportal |
| 24 | FAT3 | Ssm | 63 | 429 | 14.7% | cbioportal |
| 25 | NEB | Ssm | 62 | 429 | 14.5% | cbioportal |
| 29 | SOX9 | Ssm | 61 | 429 | 14.2% | cbioportal |
| 27 | DST | Ssm | 61 | 429 | 14.2% | cbioportal |
| 26 | BRAF | Ssm | 61 | 429 | 14.2% | cbioportal |
| 28 | LRP2 | Ssm | 61 | 429 | 14.2% | cbioportal |
| 31 | RNF43 | Ssm | 60 | 429 | 14% | cbioportal |
Data updated 21 days agoSource updated 2026-01-19