Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
273 cases with simple somatic mutation data · 273 cases total · 2026-01-05 · mapped to Appendix Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KRAS |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 161 |
| 273 |
| 59% |
| cbioportal |
| 2 | GNAS | Ssm | 91 | 273 | 33.3% | cbioportal |
| 3 | TP53 | Ssm | 86 | 273 | 31.5% | cbioportal |
| 4 | SMAD4 | Ssm | 35 | 273 | 12.8% | cbioportal |
| 5 | PIK3CA | Ssm | 26 | 273 | 9.5% | cbioportal |
| 6 | SOX9 | Ssm | 21 | 273 | 7.7% | cbioportal |
| 7 | SMAD2 | Ssm | 18 | 273 | 6.6% | cbioportal |
| 8 | ATM | Ssm | 17 | 273 | 6.2% | cbioportal |
| 9 | APC | Ssm | 15 | 273 | 5.5% | cbioportal |
| 10 | TGFBR2 | Ssm | 14 | 273 | 5.1% | cbioportal |
| 11 | RNF43 | Ssm | 13 | 273 | 4.8% | cbioportal |
| 17 | INPPL1 | Ssm | 8 | 177 | 4.5% | cbioportal |
| 12 | ARID1A | Ssm | 12 | 273 | 4.4% | cbioportal |
| 13 | FBXW7 | Ssm | 12 | 273 | 4.4% | cbioportal |
| 14 | CDH1 | Ssm | 10 | 273 | 3.7% | cbioportal |
| 15 | KMT2D | Ssm | 10 | 273 | 3.7% | cbioportal |
| 18 | MGA | Ssm | 8 | 264 | 3% | cbioportal |
| 19 | NCOR1 | Ssm | 8 | 273 | 2.9% | cbioportal |
| 16 | FAT1 | Ssm | 8 | 273 | 2.9% | cbioportal |
| 20 | SMAD3 | Ssm | 8 | 273 | 2.9% | cbioportal |
| 23 | PLCG2 | Ssm | 7 | 264 | 2.7% | cbioportal |
| 21 | AKT1 | Ssm | 7 | 273 | 2.6% | cbioportal |
| 22 | CARD11 | Ssm | 7 | 273 | 2.6% | cbioportal |
| 24 | PTPRT | Ssm | 7 | 273 | 2.6% | cbioportal |
| 50 | KMT2B | Ssm | 4 | 177 | 2.3% | cbioportal |
| 29 | NOTCH1 | Ssm | 6 | 273 | 2.2% | cbioportal |
| 27 | KDM6A | Ssm | 6 | 273 | 2.2% | cbioportal |
| 26 | BRAF | Ssm | 6 | 273 | 2.2% | cbioportal |
| 31 | PTPRS | Ssm | 6 | 273 | 2.2% | cbioportal |
| 28 | KDR | Ssm | 6 | 273 | 2.2% | cbioportal |
Data updated 21 days agoSource updated 2026-01-05