CDKN1A — gene · CancerIndex

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CDKN1A EXPRESSION1
Fluorouracil	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	B	Supports Resistance	3	accepted	EID852 112 patients with rectal cancer who received 5-FU based chemotherapy and surgery were retrospectively analyzed for expression of Ki67, TS, BAX, EpCAM, p53, p21, EGFR, CD44, CD133, CD166, HIF1α and ALD… (full text at CIViC) PMID 24708484 · Sim et al., 2014 · Open in CIViC	civic
CDKN1A rs10592341
(predisposing)	Retinoblastoma	Predisposing	B	Supports Predisposition	3	accepted	EID9244 This study examined two CDKN1A polymorphisms (rs1801270 and rs1059234) in 141 carriers of RB1 variants and 120 unrelated healthy individuals. Authors found that RB1 carriers were more likely to have t…

Cohorts

Alteration frequency by cohort (51)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved51 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Bladder Cancer (MSK, Nat Genet 2016) blca_plasmacytoid_mskcc_2016	Bladder Urothelial Carcinoma	Ssm

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer.
· BMC Cancer · 2014 · PMID 24708484 · validated civic_curation pubmed
Polymorphisms of CDKN1A gene and risk of retinoblastoma.
· Carcinogenesis · 2013 · PMID 24045412 · validated civic_curation pubmed