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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
195 cases with simple somatic mutation data · 195 cases total · 2026-04-07 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | IDH1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 48 |
| 195 |
| 24.6% |
| cbioportal |
| 2 | TP53 | Ssm | 46 | 195 | 23.6% | cbioportal |
| 3 | ARID1A | Ssm | 40 | 195 | 20.5% | cbioportal |
| 4 | BAP1 | Ssm | 26 | 195 | 13.3% | cbioportal |
| 5 | KRAS | Ssm | 23 | 195 | 11.8% | cbioportal |
| 6 | PBRM1 | Ssm | 20 | 195 | 10.3% | cbioportal |
| 7 | SMAD4 | Ssm | 16 | 195 | 8.2% | cbioportal |
| 8 | ATM | Ssm | 15 | 195 | 7.7% | cbioportal |
| 9 | KMT2C | Ssm | 13 | 195 | 6.7% | cbioportal |
| 10 | PIK3CA | Ssm | 13 | 195 | 6.7% | cbioportal |
| 11 | RASA1 | Ssm | 10 | 195 | 5.1% | cbioportal |
| 14 | NF1 | Ssm | 9 | 195 | 4.6% | cbioportal |
| 13 | KMT2D | Ssm | 9 | 195 | 4.6% | cbioportal |
| 12 | BRAF | Ssm | 9 | 195 | 4.6% | cbioportal |
| 15 | TERT | Ssm | 8 | 195 | 4.1% | cbioportal |
| 17 | NRAS | Ssm | 7 | 195 | 3.6% | cbioportal |
| 16 | ERBB3 | Ssm | 7 | 195 | 3.6% | cbioportal |
| 18 | SMARCA4 | Ssm | 6 | 195 | 3.1% | cbioportal |
| 26 | PTPRS | Ssm | 5 | 195 | 2.6% | cbioportal |
| 28 | STK11 | Ssm | 5 | 195 | 2.6% | cbioportal |
| 25 | KMT2A | Ssm | 5 | 195 | 2.6% | cbioportal |
| 27 | SF3B1 | Ssm | 5 | 195 | 2.6% | cbioportal |
| 22 | ASXL1 | Ssm | 5 | 195 | 2.6% | cbioportal |
| 24 | DOT1L | Ssm | 5 | 195 | 2.6% | cbioportal |
| 23 | CTNNB1 | Ssm | 5 | 195 | 2.6% | cbioportal |
| 21 | ARID2 | Ssm | 5 | 195 | 2.6% | cbioportal |
| 20 | ARID1B | Ssm | 5 | 195 | 2.6% | cbioportal |
| 19 | ABL1 | Ssm | 5 | 195 | 2.6% | cbioportal |
| 43 | ANKRD11 | Ssm | 3 | 141 | 2.1% | cbioportal |
| 48 | CSF3R | Ssm | 3 | 141 | 2.1% | cbioportal |
Data updated 21 days agoSource updated 2026-04-07