Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
377 cases with simple somatic mutation data · 611 cases total · 2026-01-13 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PTEN | Ssm | 126 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 377 |
| 33.4% |
| cbioportal |
| 2 | TP53 | Ssm | 121 | 377 | 32.1% | cbioportal |
| 3 | EGFR | Ssm | 85 | 377 | 22.5% | cbioportal |
| 4 | TTN | Ssm | 81 | 377 | 21.5% | cbioportal |
| 5 | MUC16 | Ssm | 49 | 377 | 13% | cbioportal |
| 6 | FLG | Ssm | 40 | 377 | 10.6% | cbioportal |
| 7 | NF1 | Ssm | 39 | 377 | 10.3% | cbioportal |
| 8 | RYR2 | Ssm | 38 | 377 | 10.1% | cbioportal |
| 9 | PIK3CA | Ssm | 36 | 377 | 9.5% | cbioportal |
| 10 | ATRX | Ssm | 35 | 377 | 9.3% | cbioportal |
| 11 | LRP2 | Ssm | 35 | 377 | 9.3% | cbioportal |
| 12 | PIK3R1 | Ssm | 35 | 377 | 9.3% | cbioportal |
| 13 | RB1 | Ssm | 34 | 377 | 9% | cbioportal |
| 14 | SPTA1 | Ssm | 28 | 377 | 7.4% | cbioportal |
| 15 | PCLO | Ssm | 27 | 377 | 7.2% | cbioportal |
| 16 | LRP1 | Ssm | 26 | 377 | 6.9% | cbioportal |
| 17 | MUC17 | Ssm | 25 | 377 | 6.6% | cbioportal |
| 18 | IDH1 | Ssm | 24 | 377 | 6.4% | cbioportal |
| 21 | PKHD1 | Ssm | 22 | 377 | 5.8% | cbioportal |
| 20 | HMCN1 | Ssm | 22 | 377 | 5.8% | cbioportal |
| 19 | AHNAK2 | Ssm | 22 | 377 | 5.8% | cbioportal |
| 22 | COL6A3 | Ssm | 21 | 377 | 5.6% | cbioportal |
| 23 | DNAH5 | Ssm | 21 | 377 | 5.6% | cbioportal |
| 24 | PIK3C2B | Ssm | 20 | 377 | 5.3% | cbioportal |
| 25 | RIMS2 | Ssm | 20 | 377 | 5.3% | cbioportal |
| 27 | OBSCN | Ssm | 19 | 377 | 5% | cbioportal |
| 28 | SYNE1 | Ssm | 19 | 377 | 5% | cbioportal |
| 29 | USH2A | Ssm | 19 | 377 | 5% | cbioportal |
| 26 | DNAH2 | Ssm | 19 | 377 | 5% | cbioportal |
| 30 | KIF2B | Ssm | 18 | 377 | 4.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13