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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
146 cases with simple somatic mutation data · 146 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 95 |
| 146 |
| 65.1% |
| cbioportal |
| 2 | TP53 | Ssm | 93 | 146 | 63.7% | cbioportal |
| 3 | TTN | Ssm | 57 | 146 | 39% | cbioportal |
| 4 | KRAS | Ssm | 47 | 146 | 32.2% | cbioportal |
| 5 | MUC16 | Ssm | 34 | 146 | 23.3% | cbioportal |
| 6 | FLG | Ssm | 28 | 146 | 19.2% | cbioportal |
| 7 | OBSCN | Ssm | 27 | 146 | 18.5% | cbioportal |
| 8 | PRRC2A | Ssm | 26 | 146 | 17.8% | cbioportal |
| 9 | MUC5B | Ssm | 25 | 146 | 17.1% | cbioportal |
| 10 | PLEC | Ssm | 25 | 146 | 17.1% | cbioportal |
| 11 | FAT3 | Ssm | 24 | 146 | 16.4% | cbioportal |
| 13 | SOX9 | Ssm | 24 | 146 | 16.4% | cbioportal |
| 12 | LRP1B | Ssm | 24 | 146 | 16.4% | cbioportal |
| 14 | FBXW7 | Ssm | 23 | 146 | 15.8% | cbioportal |
| 15 | PPFIA4 | Ssm | 23 | 146 | 15.8% | cbioportal |
| 16 | CPD | Ssm | 22 | 146 | 15.1% | cbioportal |
| 18 | RYR1 | Ssm | 22 | 146 | 15.1% | cbioportal |
| 17 | HYDIN | Ssm | 22 | 146 | 15.1% | cbioportal |
| 21 | MTUS2 | Ssm | 21 | 146 | 14.4% | cbioportal |
| 19 | AHNAK2 | Ssm | 21 | 146 | 14.4% | cbioportal |
| 20 | CACNA1H | Ssm | 21 | 146 | 14.4% | cbioportal |
| 24 | NUPR2 | Ssm | 20 | 146 | 13.7% | cbioportal |
| 22 | FSIP2 | Ssm | 20 | 146 | 13.7% | cbioportal |
| 23 | MUC4 | Ssm | 20 | 146 | 13.7% | cbioportal |
| 28 | ZNF469 | Ssm | 19 | 146 | 13% | cbioportal |
| 27 | SMAD4 | Ssm | 19 | 146 | 13% | cbioportal |
| 25 | CSMD1 | Ssm | 19 | 146 | 13% | cbioportal |
| 26 | HSPG2 | Ssm | 19 | 146 | 13% | cbioportal |
| 30 | CSMD2 | Ssm | 18 | 146 | 12.3% | cbioportal |
| 34 | RYR2 | Ssm | 18 | 146 | 12.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-06