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CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
281 cases with simple somatic mutation data · 348 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 196 |
| 281 |
| 69.8% |
| cbioportal |
| 2 | TTN | Ssm | 142 | 281 | 50.5% | cbioportal |
| 3 | TP53 | Ssm | 119 | 281 | 42.3% | cbioportal |
| 4 | KRAS | Ssm | 100 | 281 | 35.6% | cbioportal |
| 5 | SYNE1 | Ssm | 90 | 281 | 32% | cbioportal |
| 6 | MUC16 | Ssm | 76 | 281 | 27% | cbioportal |
| 7 | FAT4 | Ssm | 74 | 281 | 26.3% | cbioportal |
| 8 | OBSCN | Ssm | 72 | 281 | 25.6% | cbioportal |
| 9 | RYR2 | Ssm | 66 | 281 | 23.5% | cbioportal |
| 11 | LRP1B | Ssm | 65 | 281 | 23.1% | cbioportal |
| 10 | BRAF | Ssm | 65 | 281 | 23.1% | cbioportal |
| 13 | RYR1 | Ssm | 64 | 281 | 22.8% | cbioportal |
| 12 | ACVR2A | Ssm | 64 | 281 | 22.8% | cbioportal |
| 14 | CSMD1 | Ssm | 63 | 281 | 22.4% | cbioportal |
| 15 | DNAH5 | Ssm | 62 | 281 | 22.1% | cbioportal |
| 16 | PCLO | Ssm | 61 | 281 | 21.7% | cbioportal |
| 17 | CSMD3 | Ssm | 60 | 281 | 21.4% | cbioportal |
| 18 | MUC5B | Ssm | 57 | 281 | 20.3% | cbioportal |
| 19 | ZFHX4 | Ssm | 57 | 281 | 20.3% | cbioportal |
| 20 | FAT2 | Ssm | 56 | 281 | 19.9% | cbioportal |
| 21 | FSIP2 | Ssm | 56 | 281 | 19.9% | cbioportal |
| 23 | USH2A | Ssm | 55 | 281 | 19.6% | cbioportal |
| 22 | RYR3 | Ssm | 55 | 281 | 19.6% | cbioportal |
| 24 | DMD | Ssm | 54 | 281 | 19.2% | cbioportal |
| 25 | FAT3 | Ssm | 54 | 281 | 19.2% | cbioportal |
| 27 | SACS | Ssm | 52 | 281 | 18.5% | cbioportal |
| 26 | ABCA13 | Ssm | 52 | 281 | 18.5% | cbioportal |
| 28 | ZNF469 | Ssm | 52 | 281 | 18.5% | cbioportal |
| 31 | SPTA1 | Ssm | 51 | 281 | 18.1% | cbioportal |
| 30 | PLEC | Ssm | 51 | 281 | 18.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-06