ZRSR2

zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2

Explore in graph →CI-GENE-00040205HGNC:23019 ENSG00000169249 NCBI 8233 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ZRSR2 MUTATION1
(diagnostic)	Acute Myeloid LeukemiaCURATED_BROADER	Diagnostic	B	Supports Positive	2	submitted	EID7466 ZRSR2 is part of the spliceosome. Mutation in SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, or STAG2 was >95% specific for the diagnosis of secondary-AML PMID 25550361 · Lindsley et al., 2015 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (30)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved30 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Myelodysplasia (UTokyo, Nature 2011) mds_tokyo_2011	Myelodysplastic Syndrome	Ssm	5	29

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.