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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
474 cases with simple somatic mutation data · 476 cases total · 2026-01-27 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 245 |
| 474 |
| 51.7% |
| cbioportal |
| 2 | TTN | Ssm | 155 | 474 | 32.7% | cbioportal |
| 3 | KMT2D | Ssm | 139 | 474 | 29.3% | cbioportal |
| 4 | ARID1A | Ssm | 127 | 474 | 26.8% | cbioportal |
| 5 | KDM6A | Ssm | 124 | 474 | 26.2% | cbioportal |
| 6 | PIK3CA | Ssm | 103 | 474 | 21.7% | cbioportal |
| 7 | MUC16 | Ssm | 101 | 474 | 21.3% | cbioportal |
| 8 | TERT | Ssm | 101 | 474 | 21.3% | cbioportal |
| 9 | RB1 | Ssm | 100 | 474 | 21.1% | cbioportal |
| 10 | KMT2C | Ssm | 80 | 474 | 16.9% | cbioportal |
| 11 | EP300 | Ssm | 70 | 474 | 14.8% | cbioportal |
| 12 | ERBB2 | Ssm | 70 | 474 | 14.8% | cbioportal |
| 13 | SYNE1 | Ssm | 66 | 474 | 13.9% | cbioportal |
| 14 | ERBB3 | Ssm | 65 | 474 | 13.7% | cbioportal |
| 15 | RYR2 | Ssm | 64 | 474 | 13.5% | cbioportal |
| 16 | FGFR3 | Ssm | 60 | 474 | 12.7% | cbioportal |
| 17 | ATM | Ssm | 58 | 474 | 12.2% | cbioportal |
| 18 | FAT1 | Ssm | 58 | 474 | 12.2% | cbioportal |
| 20 | CREBBP | Ssm | 56 | 474 | 11.8% | cbioportal |
| 19 | BIRC6 | Ssm | 56 | 474 | 11.8% | cbioportal |
| 21 | HMCN1 | Ssm | 55 | 474 | 11.6% | cbioportal |
| 22 | STAG2 | Ssm | 55 | 474 | 11.6% | cbioportal |
| 23 | MACF1 | Ssm | 54 | 474 | 11.4% | cbioportal |
| 25 | KMT2A | Ssm | 53 | 474 | 11.2% | cbioportal |
| 24 | FLG | Ssm | 53 | 474 | 11.2% | cbioportal |
| 26 | FAT4 | Ssm | 52 | 474 | 11% | cbioportal |
| 27 | ERCC2 | Ssm | 50 | 474 | 10.5% | cbioportal |
| 29 | ELF3 | Ssm | 48 | 474 | 10.1% | cbioportal |
| 28 | CSMD3 | Ssm | 48 | 474 | 10.1% | cbioportal |
| 30 | BRCA2 | Ssm | 47 | 474 | 9.9% | cbioportal |
Data updated 21 days agoSource updated 2026-01-27