Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
629 cases with simple somatic mutation data · 693 cases total · 2026-08-20 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 273 |
| 629 |
| 43.4% |
| cbioportal |
| 2 | IDH1 | Ssm | 227 | 629 | 36.1% | cbioportal |
| 3 | TTN | Ssm | 147 | 629 | 23.4% | cbioportal |
| 4 | PTEN | Ssm | 143 | 629 | 22.7% | cbioportal |
| 5 | ATRX | Ssm | 139 | 629 | 22.1% | cbioportal |
| 6 | EGFR | Ssm | 112 | 629 | 17.8% | cbioportal |
| 7 | MUC16 | Ssm | 106 | 629 | 16.9% | cbioportal |
| 8 | NF1 | Ssm | 97 | 629 | 15.4% | cbioportal |
| 9 | RYR2 | Ssm | 81 | 629 | 12.9% | cbioportal |
| 10 | OBSCN | Ssm | 70 | 629 | 11.1% | cbioportal |
| 11 | PIK3CA | Ssm | 69 | 629 | 11% | cbioportal |
| 12 | PKHD1 | Ssm | 66 | 629 | 10.5% | cbioportal |
| 13 | MUC17 | Ssm | 65 | 629 | 10.3% | cbioportal |
| 14 | MUC12 | Ssm | 62 | 629 | 9.9% | cbioportal |
| 15 | FLG | Ssm | 61 | 629 | 9.7% | cbioportal |
| 17 | HMCN1 | Ssm | 58 | 629 | 9.2% | cbioportal |
| 16 | ADGRV1 | Ssm | 58 | 629 | 9.2% | cbioportal |
| 19 | LRP2 | Ssm | 56 | 629 | 8.9% | cbioportal |
| 18 | AHNAK2 | Ssm | 56 | 629 | 8.9% | cbioportal |
| 22 | RYR1 | Ssm | 54 | 629 | 8.6% | cbioportal |
| 21 | PCLO | Ssm | 54 | 629 | 8.6% | cbioportal |
| 20 | CSMD3 | Ssm | 54 | 629 | 8.6% | cbioportal |
| 23 | CIC | Ssm | 53 | 629 | 8.4% | cbioportal |
| 24 | DNAH11 | Ssm | 52 | 629 | 8.3% | cbioportal |
| 26 | NEB | Ssm | 51 | 629 | 8.1% | cbioportal |
| 25 | MUC5B | Ssm | 51 | 629 | 8.1% | cbioportal |
| 27 | DNAH5 | Ssm | 49 | 629 | 7.8% | cbioportal |
| 28 | RB1 | Ssm | 49 | 629 | 7.8% | cbioportal |
| 29 | USH2A | Ssm | 48 | 629 | 7.6% | cbioportal |
| 30 | AHNAK | Ssm | 47 | 629 | 7.5% | cbioportal |
Data updated 21 days agoSource updated 2026-08-20