Gene
H3-4
H3.4 histone, cluster member
Explore in graph →CI-GENE-00004004HGNC:4778 ENSG00000168148 NCBI 8290 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (13)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 37769223
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Hepatocellular Carcinoma (MSK, JCO Precis Oncol 2023) hcc_jcopo_msk_2023 | Hepatocellular Carcinoma | Ssm | 2 | 35 | 5.7% | 39 | cbioportal |
| Mixed Tumors Selpercatinib RET Trial (MSK, Nat Commun. 2022) mixed_selpercatinib_2020 | unmapped | Ssm | 3 | 58 | 5.2% | 42 | cbioportal |
| Mature T and NK Neoplasms (MSK, Blood Adv 2023) mtnn_msk_2022 | T-Cell Non-Hodgkin Lymphoma | Ssm | 1 | 29 | 3.4% | 148 | cbioportal |
| Breast Cancer (MSK, Nature Cancer 2020) breast_alpelisib_2020 | unmapped | Ssm | 1 | 30 | 3.3% | 91 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.