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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
200 cases with simple somatic mutation data · 200 cases total · 2026-01-07 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | FLT3 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 56 |
| 200 |
| 28% |
| cbioportal |
| 2 | NPM1 | Ssm | 54 | 200 | 27% | cbioportal |
| 3 | DNMT3A | Ssm | 49 | 200 | 24.5% | cbioportal |
| 4 | IDH2 | Ssm | 20 | 200 | 10% | cbioportal |
| 5 | IDH1 | Ssm | 19 | 200 | 9.5% | cbioportal |
| 6 | RUNX1 | Ssm | 17 | 200 | 8.5% | cbioportal |
| 7 | TET2 | Ssm | 17 | 200 | 8.5% | cbioportal |
| 8 | TP53 | Ssm | 16 | 200 | 8% | cbioportal |
| 9 | NRAS | Ssm | 15 | 200 | 7.5% | cbioportal |
| 10 | CEBPA | Ssm | 13 | 200 | 6.5% | cbioportal |
| 11 | WT1 | Ssm | 12 | 200 | 6% | cbioportal |
| 12 | PTPN11 | Ssm | 9 | 200 | 4.5% | cbioportal |
| 14 | KRAS | Ssm | 8 | 200 | 4% | cbioportal |
| 13 | KIT | Ssm | 8 | 200 | 4% | cbioportal |
| 15 | U2AF1 | Ssm | 8 | 200 | 4% | cbioportal |
| 17 | SMC3 | Ssm | 7 | 200 | 3.5% | cbioportal |
| 16 | SMC1A | Ssm | 7 | 200 | 3.5% | cbioportal |
| 19 | STAG2 | Ssm | 6 | 200 | 3% | cbioportal |
| 18 | PHF6 | Ssm | 6 | 200 | 3% | cbioportal |
| 20 | TTN | Ssm | 6 | 200 | 3% | cbioportal |
| 22 | BRINP3 | Ssm | 5 | 200 | 2.5% | cbioportal |
| 21 | ASXL1 | Ssm | 5 | 200 | 2.5% | cbioportal |
| 23 | PLCE1 | Ssm | 4 | 200 | 2% | cbioportal |
| 24 | RAD21 | Ssm | 4 | 200 | 2% | cbioportal |
| 31 | DNAH9 | Ssm | 3 | 200 | 1.5% | cbioportal |
| 25 | CACNA1B | Ssm | 3 | 200 | 1.5% | cbioportal |
| 41 | SUZ12 | Ssm | 3 | 200 | 1.5% | cbioportal |
| 40 | SPEN | Ssm | 3 | 200 | 1.5% | cbioportal |
| 39 | SMG1 | Ssm | 3 | 200 | 1.5% | cbioportal |
| 38 | PTPRT | Ssm | 3 | 200 | 1.5% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07