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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
322 cases with simple somatic mutation data · 322 cases total · 2026-01-05 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 229 |
| 322 |
| 71.1% |
| cbioportal |
| 2 | KRAS | Ssm | 90 | 322 | 28% | cbioportal |
| 3 | EGFR | Ssm | 74 | 322 | 23% | cbioportal |
| 4 | KEAP1 | Ssm | 69 | 322 | 21.4% | cbioportal |
| 5 | STK11 | Ssm | 60 | 322 | 18.6% | cbioportal |
| 6 | PTPRT | Ssm | 46 | 322 | 14.3% | cbioportal |
| 7 | ARID1A | Ssm | 44 | 322 | 13.7% | cbioportal |
| 8 | SMARCA4 | Ssm | 42 | 322 | 13% | cbioportal |
| 9 | PTPRD | Ssm | 38 | 322 | 11.8% | cbioportal |
| 10 | ATM | Ssm | 37 | 322 | 11.5% | cbioportal |
| 11 | KMT2D | Ssm | 37 | 322 | 11.5% | cbioportal |
| 12 | FAT1 | Ssm | 35 | 322 | 10.9% | cbioportal |
| 13 | NF1 | Ssm | 32 | 322 | 9.9% | cbioportal |
| 17 | ZFHX3 | Ssm | 30 | 304 | 9.9% | cbioportal |
| 30 | PREX2 | Ssm | 23 | 236 | 9.7% | cbioportal |
| 14 | CDKN2A | Ssm | 31 | 322 | 9.6% | cbioportal |
| 16 | KMT2C | Ssm | 30 | 322 | 9.3% | cbioportal |
| 15 | EPHA5 | Ssm | 30 | 322 | 9.3% | cbioportal |
| 18 | RB1 | Ssm | 29 | 322 | 9% | cbioportal |
| 19 | APC | Ssm | 28 | 322 | 8.7% | cbioportal |
| 22 | RBM10 | Ssm | 27 | 322 | 8.4% | cbioportal |
| 21 | HGF | Ssm | 27 | 322 | 8.4% | cbioportal |
| 20 | EPHA3 | Ssm | 27 | 322 | 8.4% | cbioportal |
| 24 | PIK3CA | Ssm | 26 | 322 | 8.1% | cbioportal |
| 23 | CREBBP | Ssm | 26 | 322 | 8.1% | cbioportal |
| 25 | SETD2 | Ssm | 25 | 322 | 7.8% | cbioportal |
| 29 | MGA | Ssm | 23 | 304 | 7.6% | cbioportal |
| 26 | ALK | Ssm | 24 | 322 | 7.5% | cbioportal |
| 27 | PDGFRA | Ssm | 24 | 322 | 7.5% | cbioportal |
| 28 | FLT4 | Ssm | 23 | 322 | 7.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-05