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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
286 cases with simple somatic mutation data · 530 cases total · 2026-01-07 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | IDH1 | Ssm | 221 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 286 |
| 77.3% |
| cbioportal |
| 2 | TP53 | Ssm | 146 | 286 | 51% | cbioportal |
| 3 | ATRX | Ssm | 118 | 286 | 41.3% | cbioportal |
| 4 | CIC | Ssm | 56 | 286 | 19.6% | cbioportal |
| 5 | NOTCH1 | Ssm | 31 | 286 | 10.8% | cbioportal |
| 6 | TTN | Ssm | 26 | 286 | 9.1% | cbioportal |
| 7 | FUBP1 | Ssm | 25 | 286 | 8.7% | cbioportal |
| 8 | PIK3CA | Ssm | 24 | 286 | 8.4% | cbioportal |
| 9 | NF1 | Ssm | 17 | 286 | 5.9% | cbioportal |
| 11 | MUC16 | Ssm | 15 | 286 | 5.2% | cbioportal |
| 10 | EGFR | Ssm | 15 | 286 | 5.2% | cbioportal |
| 12 | PIK3R1 | Ssm | 14 | 286 | 4.9% | cbioportal |
| 14 | SMARCA4 | Ssm | 13 | 286 | 4.5% | cbioportal |
| 13 | PTEN | Ssm | 13 | 286 | 4.5% | cbioportal |
| 15 | ARID1A | Ssm | 12 | 286 | 4.2% | cbioportal |
| 16 | IDH2 | Ssm | 12 | 286 | 4.2% | cbioportal |
| 17 | ZBTB20 | Ssm | 10 | 286 | 3.5% | cbioportal |
| 18 | APOB | Ssm | 9 | 286 | 3.1% | cbioportal |
| 21 | OBSCN | Ssm | 9 | 286 | 3.1% | cbioportal |
| 22 | RYR2 | Ssm | 9 | 286 | 3.1% | cbioportal |
| 19 | BCOR | Ssm | 9 | 286 | 3.1% | cbioportal |
| 20 | FLG | Ssm | 9 | 286 | 3.1% | cbioportal |
| 25 | TCF12 | Ssm | 8 | 286 | 2.8% | cbioportal |
| 24 | PKHD1 | Ssm | 8 | 286 | 2.8% | cbioportal |
| 23 | FAT2 | Ssm | 8 | 286 | 2.8% | cbioportal |
| 28 | MYH2 | Ssm | 7 | 286 | 2.4% | cbioportal |
| 27 | MUC17 | Ssm | 7 | 286 | 2.4% | cbioportal |
| 26 | LRP2 | Ssm | 7 | 286 | 2.4% | cbioportal |
| 39 | MYH8 | Ssm | 6 | 286 | 2.1% | cbioportal |
| 36 | LAMA3 | Ssm | 6 | 286 | 2.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07