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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
511 cases with simple somatic mutation data · 547 cases total · 2026-01-14 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PTEN | Ssm | 334 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 511 |
| 65.4% |
| cbioportal |
| 2 | PIK3CA | Ssm | 252 | 511 | 49.3% | cbioportal |
| 3 | ARID1A | Ssm | 235 | 511 | 46% | cbioportal |
| 4 | TTN | Ssm | 194 | 511 | 38% | cbioportal |
| 5 | TP53 | Ssm | 190 | 511 | 37.2% | cbioportal |
| 6 | PIK3R1 | Ssm | 166 | 511 | 32.5% | cbioportal |
| 7 | KMT2D | Ssm | 140 | 511 | 27.4% | cbioportal |
| 8 | CTNNB1 | Ssm | 130 | 511 | 25.4% | cbioportal |
| 9 | MUC16 | Ssm | 127 | 511 | 24.9% | cbioportal |
| 10 | CTCF | Ssm | 126 | 511 | 24.7% | cbioportal |
| 11 | CSMD3 | Ssm | 121 | 511 | 23.7% | cbioportal |
| 12 | ZFHX3 | Ssm | 118 | 511 | 23.1% | cbioportal |
| 13 | RYR2 | Ssm | 116 | 511 | 22.7% | cbioportal |
| 14 | KMT2B | Ssm | 114 | 511 | 22.3% | cbioportal |
| 15 | OBSCN | Ssm | 111 | 511 | 21.7% | cbioportal |
| 16 | DST | Ssm | 109 | 511 | 21.3% | cbioportal |
| 18 | ZFHX4 | Ssm | 105 | 511 | 20.5% | cbioportal |
| 17 | MUC5B | Ssm | 105 | 511 | 20.5% | cbioportal |
| 19 | CHD4 | Ssm | 104 | 511 | 20.4% | cbioportal |
| 20 | FAT1 | Ssm | 104 | 511 | 20.4% | cbioportal |
| 21 | SYNE1 | Ssm | 103 | 511 | 20.2% | cbioportal |
| 23 | MACF1 | Ssm | 102 | 511 | 20% | cbioportal |
| 22 | DNAH7 | Ssm | 102 | 511 | 20% | cbioportal |
| 24 | FAT4 | Ssm | 101 | 511 | 19.8% | cbioportal |
| 25 | TAF1 | Ssm | 101 | 511 | 19.8% | cbioportal |
| 27 | PCLO | Ssm | 98 | 511 | 19.2% | cbioportal |
| 26 | ARHGAP35 | Ssm | 98 | 511 | 19.2% | cbioportal |
| 33 | USH2A | Ssm | 96 | 511 | 18.8% | cbioportal |
| 28 | ATM | Ssm | 96 | 511 | 18.8% | cbioportal |
| 32 | LRP1B | Ssm | 96 | 511 | 18.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-14