Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
512 cases with simple somatic mutation data · 530 cases total · 2026-01-07 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 366 |
| 512 |
| 71.5% |
| cbioportal |
| 2 | TTN | Ssm | 217 | 512 | 42.4% | cbioportal |
| 3 | FAT1 | Ssm | 115 | 512 | 22.5% | cbioportal |
| 4 | CDKN2A | Ssm | 113 | 512 | 22.1% | cbioportal |
| 5 | FRG1BP | Ssm | 106 | 512 | 20.7% | cbioportal |
| 6 | CSMD3 | Ssm | 105 | 512 | 20.5% | cbioportal |
| 7 | MUC16 | Ssm | 102 | 512 | 19.9% | cbioportal |
| 8 | PIK3CA | Ssm | 94 | 512 | 18.4% | cbioportal |
| 9 | SYNE1 | Ssm | 92 | 512 | 18% | cbioportal |
| 10 | NOTCH1 | Ssm | 91 | 512 | 17.8% | cbioportal |
| 11 | LRP1B | Ssm | 90 | 512 | 17.6% | cbioportal |
| 12 | KMT2D | Ssm | 84 | 512 | 16.4% | cbioportal |
| 13 | PCLO | Ssm | 82 | 512 | 16% | cbioportal |
| 14 | FLG | Ssm | 76 | 512 | 14.8% | cbioportal |
| 15 | DNAH5 | Ssm | 70 | 512 | 13.7% | cbioportal |
| 16 | USH2A | Ssm | 65 | 512 | 12.7% | cbioportal |
| 17 | NSD1 | Ssm | 62 | 512 | 12.1% | cbioportal |
| 18 | RYR2 | Ssm | 60 | 512 | 11.7% | cbioportal |
| 19 | PKHD1L1 | Ssm | 57 | 512 | 11.1% | cbioportal |
| 20 | XIRP2 | Ssm | 55 | 512 | 10.7% | cbioportal |
| 21 | CASP8 | Ssm | 54 | 512 | 10.5% | cbioportal |
| 22 | SI | Ssm | 54 | 512 | 10.5% | cbioportal |
| 23 | AHNAK | Ssm | 51 | 512 | 10% | cbioportal |
| 24 | DMD | Ssm | 50 | 512 | 9.8% | cbioportal |
| 25 | FAM135B | Ssm | 50 | 512 | 9.8% | cbioportal |
| 26 | COL11A1 | Ssm | 49 | 512 | 9.6% | cbioportal |
| 30 | RELN | Ssm | 46 | 512 | 9% | cbioportal |
| 27 | HUWE1 | Ssm | 46 | 512 | 9% | cbioportal |
| 29 | PCDH15 | Ssm | 46 | 512 | 9% | cbioportal |
| 28 | PAPPA2 | Ssm | 46 | 512 | 9% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07