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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
566 cases with simple somatic mutation data · 566 cases total · 2026-06-04 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 1 |
| TP53 |
| Ssm |
| 295 |
| 566 |
| 52.1% |
| cbioportal |
| 2 | TTN | Ssm | 272 | 566 | 48.1% | cbioportal |
| 3 | MUC16 | Ssm | 242 | 566 | 42.8% | cbioportal |
| 4 | CSMD3 | Ssm | 226 | 566 | 39.9% | cbioportal |
| 5 | RYR2 | Ssm | 217 | 566 | 38.3% | cbioportal |
| 6 | LRP1B | Ssm | 201 | 566 | 35.5% | cbioportal |
| 7 | ZFHX4 | Ssm | 185 | 566 | 32.7% | cbioportal |
| 8 | USH2A | Ssm | 177 | 566 | 31.3% | cbioportal |
| 9 | KRAS | Ssm | 168 | 566 | 29.7% | cbioportal |
| 10 | XIRP2 | Ssm | 150 | 566 | 26.5% | cbioportal |
| 11 | SPTA1 | Ssm | 148 | 566 | 26.1% | cbioportal |
| 12 | FLG | Ssm | 145 | 566 | 25.6% | cbioportal |
| 13 | CSMD1 | Ssm | 125 | 566 | 22.1% | cbioportal |
| 14 | NAV3 | Ssm | 123 | 566 | 21.7% | cbioportal |
| 15 | FAT3 | Ssm | 121 | 566 | 21.4% | cbioportal |
| 16 | COL11A1 | Ssm | 120 | 566 | 21.2% | cbioportal |
| 17 | PCDH15 | Ssm | 118 | 566 | 20.8% | cbioportal |
| 18 | ZNF536 | Ssm | 117 | 566 | 20.7% | cbioportal |
| 19 | ANK2 | Ssm | 111 | 566 | 19.6% | cbioportal |
| 20 | MUC17 | Ssm | 111 | 566 | 19.6% | cbioportal |
| 21 | PCLO | Ssm | 109 | 566 | 19.3% | cbioportal |
| 22 | RYR3 | Ssm | 106 | 566 | 18.7% | cbioportal |
| 23 | APOB | Ssm | 104 | 566 | 18.4% | cbioportal |
| 24 | KEAP1 | Ssm | 102 | 566 | 18% | cbioportal |
| 25 | PAPPA2 | Ssm | 101 | 566 | 17.8% | cbioportal |
| 27 | DNAH9 | Ssm | 99 | 566 | 17.5% | cbioportal |
| 26 | ADAMTS12 | Ssm | 99 | 566 | 17.5% | cbioportal |
| 28 | ADGRG4 | Ssm | 98 | 566 | 17.3% | cbioportal |
| 29 | RP1L1 | Ssm | 97 | 566 | 17.1% | cbioportal |
| 31 | TNR | Ssm | 95 | 566 | 16.8% | cbioportal |
Data updated 21 days agoSource updated 2026-06-04