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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
64 cases with simple somatic mutation data · 64 cases total · 2026-01-07 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| TP53 |
| Ssm |
| 37 |
| 64 |
| 57.8% |
| cbioportal |
| 2 | KRAS | Ssm | 35 | 64 | 54.7% | cbioportal |
| 3 | APC | Ssm | 28 | 64 | 43.8% | cbioportal |
| 4 | PIK3CA | Ssm | 16 | 64 | 25% | cbioportal |
| 9 | TCF7L2 | Ssm | 13 | 55 | 23.6% | cbioportal |
| 5 | ARID1A | Ssm | 15 | 64 | 23.4% | cbioportal |
| 6 | CREBBP | Ssm | 14 | 64 | 21.9% | cbioportal |
| 7 | KMT2C | Ssm | 13 | 64 | 20.3% | cbioportal |
| 8 | PTPRS | Ssm | 13 | 64 | 20.3% | cbioportal |
| 18 | ZFHX3 | Ssm | 10 | 55 | 18.2% | cbioportal |
| 12 | SOX9 | Ssm | 11 | 64 | 17.2% | cbioportal |
| 11 | PTPRT | Ssm | 11 | 64 | 17.2% | cbioportal |
| 10 | CIC | Ssm | 11 | 64 | 17.2% | cbioportal |
| 13 | SPEN | Ssm | 11 | 64 | 17.2% | cbioportal |
| 16 | KMT2D | Ssm | 10 | 64 | 15.6% | cbioportal |
| 17 | RNF43 | Ssm | 10 | 64 | 15.6% | cbioportal |
| 14 | AMER1 | Ssm | 10 | 64 | 15.6% | cbioportal |
| 15 | FAT1 | Ssm | 10 | 64 | 15.6% | cbioportal |
| 21 | NOTCH1 | Ssm | 9 | 64 | 14.1% | cbioportal |
| 23 | POLE | Ssm | 9 | 64 | 14.1% | cbioportal |
| 22 | NOTCH3 | Ssm | 9 | 64 | 14.1% | cbioportal |
| 20 | FLT4 | Ssm | 9 | 64 | 14.1% | cbioportal |
| 19 | ALK | Ssm | 9 | 64 | 14.1% | cbioportal |
| 24 | ABL1 | Ssm | 8 | 64 | 12.5% | cbioportal |
| 31 | TET1 | Ssm | 8 | 64 | 12.5% | cbioportal |
| 28 | NOTCH4 | Ssm | 8 | 64 | 12.5% | cbioportal |
| 29 | PIK3R1 | Ssm | 8 | 64 | 12.5% | cbioportal |
| 30 | RPS6KA4 | Ssm | 8 | 64 | 12.5% | cbioportal |
| 26 | BRCA2 | Ssm | 8 | 64 | 12.5% | cbioportal |
| 25 | ARID1B | Ssm | 8 | 64 | 12.5% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07