Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
155 cases with simple somatic mutation data · 171 cases total · 2026-01-13 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC | Ssm | 126 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 155 |
| 81.3% |
| cbioportal |
| 2 | TP53 | Ssm | 110 | 155 | 71% | cbioportal |
| 3 | KRAS | Ssm | 63 | 155 | 40.6% | cbioportal |
| 4 | TTN | Ssm | 61 | 155 | 39.4% | cbioportal |
| 5 | SYNE1 | Ssm | 35 | 155 | 22.6% | cbioportal |
| 6 | MUC16 | Ssm | 28 | 155 | 18.1% | cbioportal |
| 7 | FBXW7 | Ssm | 26 | 155 | 16.8% | cbioportal |
| 8 | FAT4 | Ssm | 25 | 155 | 16.1% | cbioportal |
| 9 | RYR2 | Ssm | 25 | 155 | 16.1% | cbioportal |
| 10 | LRP1B | Ssm | 24 | 155 | 15.5% | cbioportal |
| 12 | SMAD4 | Ssm | 23 | 155 | 14.8% | cbioportal |
| 11 | CSMD1 | Ssm | 23 | 155 | 14.8% | cbioportal |
| 13 | PIK3CA | Ssm | 22 | 155 | 14.2% | cbioportal |
| 15 | FAT3 | Ssm | 19 | 155 | 12.3% | cbioportal |
| 14 | DNAH11 | Ssm | 19 | 155 | 12.3% | cbioportal |
| 16 | SACS | Ssm | 18 | 155 | 11.6% | cbioportal |
| 17 | CSMD3 | Ssm | 17 | 155 | 11% | cbioportal |
| 19 | ZFHX4 | Ssm | 17 | 155 | 11% | cbioportal |
| 18 | OBSCN | Ssm | 17 | 155 | 11% | cbioportal |
| 20 | FLG | Ssm | 16 | 155 | 10.3% | cbioportal |
| 21 | HYDIN | Ssm | 16 | 155 | 10.3% | cbioportal |
| 22 | ABCA13 | Ssm | 15 | 155 | 9.7% | cbioportal |
| 23 | ATM | Ssm | 15 | 155 | 9.7% | cbioportal |
| 27 | RYR1 | Ssm | 15 | 155 | 9.7% | cbioportal |
| 28 | SPTA1 | Ssm | 15 | 155 | 9.7% | cbioportal |
| 29 | TCF7L2 | Ssm | 15 | 155 | 9.7% | cbioportal |
| 26 | NRAS | Ssm | 15 | 155 | 9.7% | cbioportal |
| 24 | DNAH7 | Ssm | 15 | 155 | 9.7% | cbioportal |
| 25 | NBEA | Ssm | 15 | 155 | 9.7% | cbioportal |
| 33 | RIMS1 | Ssm | 14 | 155 | 9% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13