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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
139 cases with simple somatic mutation data · 139 cases total · 2026-01-07 · mapped to Esophageal Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 83 |
| 139 |
| 59.7% |
| cbioportal |
| 2 | TTN | Ssm | 49 | 139 | 35.3% | cbioportal |
| 152 | MYH2 | Ssm | 4 | 20 | 20% | cbioportal |
| 180 | ZNF676 | Ssm | 4 | 20 | 20% | cbioportal |
| 3 | KMT2D | Ssm | 25 | 139 | 18% | cbioportal |
| 4 | MUC16 | Ssm | 20 | 139 | 14.4% | cbioportal |
| 5 | SYNE1 | Ssm | 18 | 139 | 12.9% | cbioportal |
| 6 | FAT1 | Ssm | 16 | 139 | 11.5% | cbioportal |
| 9 | LRP1B | Ssm | 15 | 139 | 10.8% | cbioportal |
| 8 | CSMD3 | Ssm | 15 | 139 | 10.8% | cbioportal |
| 7 | ADGRV1 | Ssm | 15 | 139 | 10.8% | cbioportal |
| 10 | PCLO | Ssm | 14 | 139 | 10.1% | cbioportal |
| 11 | XIRP2 | Ssm | 13 | 139 | 9.4% | cbioportal |
| 13 | FAT2 | Ssm | 12 | 139 | 8.6% | cbioportal |
| 15 | MUC4 | Ssm | 12 | 139 | 8.6% | cbioportal |
| 14 | HMCN1 | Ssm | 12 | 139 | 8.6% | cbioportal |
| 12 | ABCA13 | Ssm | 12 | 139 | 8.6% | cbioportal |
| 16 | DMD | Ssm | 11 | 139 | 7.9% | cbioportal |
| 26 | RB1 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 25 | PIK3CA | Ssm | 11 | 139 | 7.9% | cbioportal |
| 24 | NOTCH1 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 23 | MUC2 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 22 | MUC17 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 21 | LRP2 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 20 | KMT2C | Ssm | 11 | 139 | 7.9% | cbioportal |
| 19 | FSIP2 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 18 | EP300 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 17 | DNAH5 | Ssm | 11 | 139 | 7.9% | cbioportal |
| 32 | ZNF750 | Ssm | 10 | 139 | 7.2% | cbioportal |
| 27 | DNAH6 | Ssm | 10 | 139 | 7.2% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07