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CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
182 cases with simple somatic mutation data · 182 cases total · 2026-06-05 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 1 |
| TP53 |
| Ssm |
| 158 |
| 182 |
| 86.8% |
| cbioportal |
| 2 | TTN | Ssm | 75 | 182 | 41.2% | cbioportal |
| 3 | MUC16 | Ssm | 43 | 182 | 23.6% | cbioportal |
| 4 | SYNE1 | Ssm | 37 | 182 | 20.3% | cbioportal |
| 5 | CSMD3 | Ssm | 35 | 182 | 19.2% | cbioportal |
| 6 | FLG | Ssm | 32 | 182 | 17.6% | cbioportal |
| 7 | HMCN1 | Ssm | 31 | 182 | 17% | cbioportal |
| 8 | LRP1B | Ssm | 31 | 182 | 17% | cbioportal |
| 9 | DNAH5 | Ssm | 30 | 182 | 16.5% | cbioportal |
| 10 | PCLO | Ssm | 27 | 182 | 14.8% | cbioportal |
| 11 | RYR2 | Ssm | 23 | 182 | 12.6% | cbioportal |
| 13 | KMT2D | Ssm | 22 | 182 | 12.1% | cbioportal |
| 12 | EYS | Ssm | 22 | 182 | 12.1% | cbioportal |
| 14 | CSMD1 | Ssm | 21 | 182 | 11.5% | cbioportal |
| 18 | UNC13C | Ssm | 20 | 182 | 11% | cbioportal |
| 15 | FAT3 | Ssm | 20 | 182 | 11% | cbioportal |
| 16 | PKHD1L1 | Ssm | 20 | 182 | 11% | cbioportal |
| 17 | SPTA1 | Ssm | 20 | 182 | 11% | cbioportal |
| 21 | PCDH15 | Ssm | 19 | 182 | 10.4% | cbioportal |
| 20 | OBSCN | Ssm | 19 | 182 | 10.4% | cbioportal |
| 19 | DYNC2H1 | Ssm | 19 | 182 | 10.4% | cbioportal |
| 22 | ZNF804B | Ssm | 19 | 182 | 10.4% | cbioportal |
| 24 | SACS | Ssm | 18 | 182 | 9.9% | cbioportal |
| 25 | USH2A | Ssm | 18 | 182 | 9.9% | cbioportal |
| 23 | NFE2L2 | Ssm | 18 | 182 | 9.9% | cbioportal |
| 28 | LRRK2 | Ssm | 17 | 182 | 9.3% | cbioportal |
| 30 | PIK3CA | Ssm | 17 | 182 | 9.3% | cbioportal |
| 27 | LAMA1 | Ssm | 17 | 182 | 9.3% | cbioportal |
| 26 | CNTNAP5 | Ssm | 17 | 182 | 9.3% | cbioportal |
| 31 | RYR3 | Ssm | 17 | 182 | 9.3% | cbioportal |
Data updated 21 days agoSource updated 2026-06-05