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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
236 cases with simple somatic mutation data · 241 cases total · 2026-01-14 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 | Ssm | 119 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 236 |
| 50.4% |
| cbioportal |
| 2 | RYR2 | Ssm | 80 | 236 | 33.9% | cbioportal |
| 3 | CSMD3 | Ssm | 76 | 236 | 32.2% | cbioportal |
| 4 | MUC16 | Ssm | 75 | 236 | 31.8% | cbioportal |
| 6 | USH2A | Ssm | 70 | 236 | 29.7% | cbioportal |
| 5 | EGFR | Ssm | 70 | 236 | 29.7% | cbioportal |
| 7 | KRAS | Ssm | 69 | 236 | 29.2% | cbioportal |
| 8 | TTN | Ssm | 68 | 236 | 28.8% | cbioportal |
| 9 | ZFHX4 | Ssm | 57 | 236 | 24.2% | cbioportal |
| 11 | XIRP2 | Ssm | 53 | 236 | 22.5% | cbioportal |
| 10 | LRP1B | Ssm | 53 | 236 | 22.5% | cbioportal |
| 13 | FSIP2 | Ssm | 51 | 236 | 21.6% | cbioportal |
| 12 | CSMD1 | Ssm | 51 | 236 | 21.6% | cbioportal |
| 14 | LRTM3 | Ssm | 47 | 236 | 19.9% | cbioportal |
| 15 | SPTA1 | Ssm | 47 | 236 | 19.9% | cbioportal |
| 16 | FAT3 | Ssm | 45 | 236 | 19.1% | cbioportal |
| 17 | EYS | Ssm | 44 | 236 | 18.6% | cbioportal |
| 18 | MUC17 | Ssm | 44 | 236 | 18.6% | cbioportal |
| 19 | PCLO | Ssm | 42 | 236 | 17.8% | cbioportal |
| 22 | FLG | Ssm | 41 | 236 | 17.4% | cbioportal |
| 20 | APOB | Ssm | 41 | 236 | 17.4% | cbioportal |
| 21 | COL11A1 | Ssm | 41 | 236 | 17.4% | cbioportal |
| 24 | ZNF536 | Ssm | 40 | 236 | 16.9% | cbioportal |
| 23 | SYNE1 | Ssm | 40 | 236 | 16.9% | cbioportal |
| 25 | PCDH15 | Ssm | 38 | 236 | 16.1% | cbioportal |
| 26 | FAT4 | Ssm | 37 | 236 | 15.7% | cbioportal |
| 28 | STK11 | Ssm | 37 | 236 | 15.7% | cbioportal |
| 27 | NAV3 | Ssm | 37 | 236 | 15.7% | cbioportal |
| 29 | ANK2 | Ssm | 36 | 236 | 15.3% | cbioportal |
| 30 | RYR3 | Ssm | 36 | 236 | 15.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-14