Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
1,004 cases with simple somatic mutation data · 1,004 cases total · 2026-01-07 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TERT | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 604 |
| 882 |
| 68.5% |
| cbioportal |
| 2 | TP53 | Ssm | 405 | 1,004 | 40.3% | cbioportal |
| 3 | IDH1 | Ssm | 339 | 1,004 | 33.8% | cbioportal |
| 4 | PTEN | Ssm | 246 | 1,004 | 24.5% | cbioportal |
| 5 | ATRX | Ssm | 222 | 1,004 | 22.1% | cbioportal |
| 6 | EGFR | Ssm | 146 | 1,004 | 14.5% | cbioportal |
| 7 | NF1 | Ssm | 142 | 1,004 | 14.1% | cbioportal |
| 8 | CIC | Ssm | 128 | 1,004 | 12.7% | cbioportal |
| 9 | PIK3CA | Ssm | 111 | 1,004 | 11.1% | cbioportal |
| 10 | RB1 | Ssm | 86 | 1,004 | 8.6% | cbioportal |
| 11 | PIK3R1 | Ssm | 83 | 1,004 | 8.3% | cbioportal |
| 138 | LRP1B | Ssm | 13 | 167 | 7.8% | cbioportal |
| 12 | NOTCH1 | Ssm | 73 | 1,004 | 7.3% | cbioportal |
| 15 | FAT1 | Ssm | 48 | 882 | 5.4% | cbioportal |
| 13 | SETD2 | Ssm | 54 | 1,004 | 5.4% | cbioportal |
| 14 | SMARCA4 | Ssm | 51 | 1,004 | 5.1% | cbioportal |
| 16 | KMT2D | Ssm | 48 | 1,004 | 4.8% | cbioportal |
| 20 | FUBP1 | Ssm | 42 | 882 | 4.8% | cbioportal |
| 17 | PDGFRA | Ssm | 47 | 1,004 | 4.7% | cbioportal |
| 18 | ARID1A | Ssm | 44 | 1,004 | 4.4% | cbioportal |
| 19 | ARID2 | Ssm | 44 | 1,004 | 4.4% | cbioportal |
| 21 | PTPN11 | Ssm | 42 | 1,004 | 4.2% | cbioportal |
| 22 | BRAF | Ssm | 41 | 1,004 | 4.1% | cbioportal |
| 23 | STAG2 | Ssm | 40 | 1,004 | 4% | cbioportal |
| 27 | KMT2C | Ssm | 34 | 882 | 3.9% | cbioportal |
| 26 | ARID1B | Ssm | 34 | 882 | 3.9% | cbioportal |
| 24 | BCOR | Ssm | 38 | 1,004 | 3.8% | cbioportal |
| 25 | NOTCH3 | Ssm | 36 | 1,004 | 3.6% | cbioportal |
| 28 | MED12 | Ssm | 34 | 1,004 | 3.4% | cbioportal |
| 56 | ZFHX3 | Ssm | 24 | 712 | 3.4% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07