Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
527 cases with simple somatic mutation data · 527 cases total · 2026-01-20 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PIK3CA | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 316 |
| 527 |
| 60% |
| cbioportal |
| 2 | TP53 | Ssm | 288 | 527 | 54.6% | cbioportal |
| 3 | CDH1 | Ssm | 173 | 527 | 32.8% | cbioportal |
| 4 | KMT2C | Ssm | 147 | 527 | 27.9% | cbioportal |
| 5 | KMT2D | Ssm | 108 | 527 | 20.5% | cbioportal |
| 6 | NF1 | Ssm | 103 | 527 | 19.5% | cbioportal |
| 7 | ARID1A | Ssm | 92 | 527 | 17.5% | cbioportal |
| 8 | FAT1 | Ssm | 89 | 527 | 16.9% | cbioportal |
| 9 | SPEN | Ssm | 88 | 527 | 16.7% | cbioportal |
| 10 | MAP3K1 | Ssm | 87 | 527 | 16.5% | cbioportal |
| 12 | ZFHX3 | Ssm | 73 | 488 | 15% | cbioportal |
| 11 | PTEN | Ssm | 77 | 527 | 14.6% | cbioportal |
| 25 | KMT2B | Ssm | 57 | 407 | 14% | cbioportal |
| 13 | FOXA1 | Ssm | 72 | 527 | 13.7% | cbioportal |
| 21 | MGA | Ssm | 66 | 488 | 13.5% | cbioportal |
| 14 | NCOR1 | Ssm | 71 | 527 | 13.5% | cbioportal |
| 15 | BRCA2 | Ssm | 70 | 527 | 13.3% | cbioportal |
| 18 | GATA3 | Ssm | 69 | 527 | 13.1% | cbioportal |
| 16 | ATM | Ssm | 69 | 527 | 13.1% | cbioportal |
| 17 | ESR1 | Ssm | 69 | 527 | 13.1% | cbioportal |
| 19 | KMT2A | Ssm | 68 | 527 | 12.9% | cbioportal |
| 20 | TBX3 | Ssm | 67 | 527 | 12.7% | cbioportal |
| 22 | ATRX | Ssm | 61 | 527 | 11.6% | cbioportal |
| 23 | APC | Ssm | 60 | 527 | 11.4% | cbioportal |
| 24 | ATR | Ssm | 59 | 527 | 11.2% | cbioportal |
| 28 | SETD2 | Ssm | 54 | 527 | 10.2% | cbioportal |
| 26 | RB1 | Ssm | 54 | 527 | 10.2% | cbioportal |
| 27 | ROS1 | Ssm | 54 | 527 | 10.2% | cbioportal |
| 30 | NOTCH4 | Ssm | 53 | 527 | 10.1% | cbioportal |
| 29 | ARID1B | Ssm | 53 | 527 | 10.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-20