Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
696 cases with simple somatic mutation data · 696 cases total · 2026-01-08 · mapped to Cutaneous Melanoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TERT |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 575 |
| 696 |
| 82.6% |
| cbioportal |
| 2 | BRAF | Ssm | 301 | 696 | 43.2% | cbioportal |
| 3 | PTPRT | Ssm | 254 | 696 | 36.5% | cbioportal |
| 15 | PREX2 | Ssm | 141 | 437 | 32.3% | cbioportal |
| 4 | GRIN2A | Ssm | 217 | 696 | 31.2% | cbioportal |
| 5 | NRAS | Ssm | 207 | 696 | 29.7% | cbioportal |
| 6 | PTPRD | Ssm | 199 | 696 | 28.6% | cbioportal |
| 8 | ROS1 | Ssm | 194 | 696 | 27.9% | cbioportal |
| 7 | NF1 | Ssm | 194 | 696 | 27.9% | cbioportal |
| 9 | PAK5 | Ssm | 189 | 696 | 27.2% | cbioportal |
| 10 | TP53 | Ssm | 183 | 696 | 26.3% | cbioportal |
| 11 | KMT2D | Ssm | 165 | 696 | 23.7% | cbioportal |
| 12 | ERBB4 | Ssm | 161 | 696 | 23.1% | cbioportal |
| 33 | KMT2B | Ssm | 97 | 437 | 22.2% | cbioportal |
| 13 | TP63 | Ssm | 153 | 696 | 22% | cbioportal |
| 14 | PIK3C2G | Ssm | 149 | 696 | 21.4% | cbioportal |
| 17 | EPHA7 | Ssm | 140 | 658 | 21.3% | cbioportal |
| 16 | CDKN2A | Ssm | 140 | 696 | 20.1% | cbioportal |
| 18 | FAT1 | Ssm | 136 | 696 | 19.5% | cbioportal |
| 19 | KDR | Ssm | 131 | 696 | 18.8% | cbioportal |
| 20 | NOTCH4 | Ssm | 129 | 696 | 18.5% | cbioportal |
| 21 | KMT2C | Ssm | 124 | 696 | 17.8% | cbioportal |
| 22 | NOTCH3 | Ssm | 118 | 696 | 17% | cbioportal |
| 23 | KMT2A | Ssm | 117 | 696 | 16.8% | cbioportal |
| 24 | ALK | Ssm | 115 | 696 | 16.5% | cbioportal |
| 25 | FLT1 | Ssm | 111 | 696 | 15.9% | cbioportal |
| 26 | CARD11 | Ssm | 110 | 696 | 15.8% | cbioportal |
| 27 | ARID2 | Ssm | 109 | 696 | 15.7% | cbioportal |
| 31 | ZFHX3 | Ssm | 99 | 658 | 15% | cbioportal |
| 28 | APC | Ssm | 103 | 696 | 14.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-08