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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
518 cases with simple somatic mutation data · 559 cases total · 2026-01-13 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 309 |
| 518 |
| 59.7% |
| cbioportal |
| 2 | TTN | Ssm | 276 | 518 | 53.3% | cbioportal |
| 3 | MUC16 | Ssm | 171 | 518 | 33% | cbioportal |
| 4 | SYNE1 | Ssm | 134 | 518 | 25.9% | cbioportal |
| 5 | LRP1B | Ssm | 125 | 518 | 24.1% | cbioportal |
| 6 | CSMD3 | Ssm | 121 | 518 | 23.4% | cbioportal |
| 7 | FLG | Ssm | 108 | 518 | 20.8% | cbioportal |
| 8 | ARID1A | Ssm | 106 | 518 | 20.5% | cbioportal |
| 9 | CSMD1 | Ssm | 104 | 518 | 20.1% | cbioportal |
| 10 | OBSCN | Ssm | 104 | 518 | 20.1% | cbioportal |
| 11 | PCLO | Ssm | 103 | 518 | 19.9% | cbioportal |
| 13 | FAT4 | Ssm | 99 | 518 | 19.1% | cbioportal |
| 12 | DNAH5 | Ssm | 99 | 518 | 19.1% | cbioportal |
| 14 | RYR2 | Ssm | 98 | 518 | 18.9% | cbioportal |
| 15 | HMCN1 | Ssm | 92 | 518 | 17.8% | cbioportal |
| 16 | KMT2D | Ssm | 91 | 518 | 17.6% | cbioportal |
| 17 | FAT3 | Ssm | 88 | 518 | 17% | cbioportal |
| 18 | SPTA1 | Ssm | 86 | 518 | 16.6% | cbioportal |
| 19 | ZFHX4 | Ssm | 80 | 518 | 15.4% | cbioportal |
| 20 | USH2A | Ssm | 79 | 518 | 15.3% | cbioportal |
| 21 | PIK3CA | Ssm | 77 | 518 | 14.9% | cbioportal |
| 22 | PCDH15 | Ssm | 76 | 518 | 14.7% | cbioportal |
| 23 | RYR3 | Ssm | 74 | 518 | 14.3% | cbioportal |
| 24 | LRRK2 | Ssm | 72 | 518 | 13.9% | cbioportal |
| 25 | SACS | Ssm | 72 | 518 | 13.9% | cbioportal |
| 26 | DNAH11 | Ssm | 71 | 518 | 13.7% | cbioportal |
| 27 | DNAH7 | Ssm | 70 | 518 | 13.5% | cbioportal |
| 29 | DMD | Ssm | 67 | 518 | 12.9% | cbioportal |
| 30 | MUC4 | Ssm | 67 | 518 | 12.9% | cbioportal |
| 31 | NBEA | Ssm | 67 | 518 | 12.9% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13