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Drugs
One entity per molecule (INN preferred); brand names and development codes are aliases. Approvals are always shown with jurisdiction and indication.
819 drugs
| Drug | Kind | Mechanism | Approvals | Evidence items | Trials | Identifiers |
|---|---|---|---|---|---|---|
| Pembrolizumab | Monoclonal Antibody | Programmed cell death protein 1 inhibitor | 148 | 55 | 2,183 | C106432 · CHEMBL3137343 |
| Pemetrexed | Small Molecule | Thymidylate synthase inhibitor; Dihydrofolate reductase inhibitor; GAR transformylase inhibitor | 102 | 16 | 834 | C61614 · CHEMBL225072 |
| Nivolumab | Monoclonal Antibody | Programmed cell death protein 1 inhibitor | 98 | 29 | 1,426 | C68814 · CHEMBL2108738 |
| Methotrexate | Small Molecule | Dihydrofolate reductase inhibitor | 87 | 14 | 728 | C642 · CHEMBL34259 |
| Docetaxel | Small Molecule | Tubulin inhibitor; Tubulin stabiliser | 75 | 29 | 1,729 | C1526 · CHEMBL3545252 |
| Temozolomide | Small Molecule | DNA inhibitor | 68 | 36 | 781 | C1244 · CHEMBL810 |
| Imatinib | Small Molecule | Tyrosine-protein kinase ABL inhibitor; Platelet-derived growth factor receptor beta inhibitor; Stem cell growth factor receptor inhibitor; Bcr/Abl fusion protein inhibitor | 67 | 279 | 174 | C62035 · CHEMBL941 |
| Denosumab | Monoclonal Antibody | Tumor necrosis factor ligand superfamily member 11 inhibitor | 62 | 0 | 75 | CHEMBL1237023 |
| Bevacizumab | Monoclonal Antibody | Vascular endothelial growth factor A inhibitor | 52 | 48 | 1,821 | C2039 · CHEMBL1201583 |
| Gemcitabine | Small Molecule | Ribonucleoside-diphosphate reductase RR1 inhibitor; DNA polymerase (alpha/delta/epsilon) inhibitor | 52 | 43 | 2,012 | C66876 · CHEMBL888 |
| Leuprolide | Other | Gonadotropin-releasing hormone receptor agonist | 52 | 1 | 186 | C62042 · CHEMBL1201199 |
| Letrozole | Small Molecule | Cytochrome P450 19A1 inhibitor | 51 | 6 | 429 | C1527 · CHEMBL1444 |
| Bortezomib | Small Molecule | 26S proteasome inhibitor | 51 | 3 | 722 | C1851 · CHEMBL325041 |
| Trastuzumab | Monoclonal Antibody | Receptor protein-tyrosine kinase erbB-2 inhibitor | 47 | 127 | 795 | C1647 · CHEMBL1201585 |
| Capecitabine | Small Molecule | Thymidylate synthase inhibitor; DNA inhibitor; RNA inhibitor | 47 | 18 | 1,384 | C1794 · CHEMBL1773 |
| Atezolizumab | Monoclonal Antibody | Programmed cell death 1 ligand 1 inhibitor | 45 | 27 | 618 | C106250 · CHEMBL3707227 |
| Dasatinib | Small Molecule | Tyrosine-protein kinase ABL inhibitor; Platelet-derived growth factor receptor beta inhibitor; Stem cell growth factor receptor inhibitor; Ephrin type-A receptor 2 inhibitor; SRC inhibitor; Bcr/Abl fusion protein inhibitor | 43 | 319 | 273 | C38713 · CHEMBL5416410 |
| Cyclophosphamide | Small Molecule | DNA inhibitor | 43 | 1 | 2,848 | C405 · CHEMBL1200796 |
| Doxorubicin | Small Molecule | DNA topoisomerase II alpha inhibitor; DNA inhibitor | 41 | 41 | 1,373 | C456 · CHEMBL53463 |
| Ibrutinib | Small Molecule | Tyrosine-protein kinase BTK inhibitor | 41 | 12 | 285 | C81934 · CHEMBL1873475 |
| Abiraterone Acetate | Small Molecule | Cytochrome P450 17A1 inhibitor | 41 | 3 | 157 | C68845 · CHEMBL271227 |
| Palbociclib | Small Molecule | CDK6/cyclin D1 inhibitor; Cyclin-dependent kinase 4/cyclin D1 inhibitor | 40 | 92 | 283 | C49176 · CHEMBL189963 |
| Sunitinib | Small Molecule | Macrophage colony stimulating factor receptor inhibitor; Stem cell growth factor receptor inhibitor; Tyrosine-protein kinase receptor FLT3 inhibitor; Platelet-derived growth factor receptor inhibitor; Vascular endothelial growth factor receptor inhibitor; Tyrosine-protein kinase receptor RET inhibitor; Vascular endothelial growth factor receptor 2 inhibitor; Platelet-derived growth factor receptor beta inhibitor; Platelet-derived growth factor receptor alpha inhibitor; Vascular endothelial growth factor receptor 1 inhibitor; Vascular endothelial growth factor receptor 3 inhibitor | 39 | 165 | 387 | C71622 · CHEMBL535 |
| Paclitaxel | Small Molecule | Tubulin inhibitor | 39 | 35 | 2,325 | C1411 · CHEMBL428647 |
| Anastrozole | Small Molecule | Cytochrome P450 19A1 inhibitor | 39 | 0 | 205 | CHEMBL1399 |
| Fulvestrant | Small Molecule | Estrogen receptor alpha antagonist; Estrogen receptor degrader | 37 | 58 | 384 | C1379 · CHEMBL1358 |
| Rituximab | Monoclonal Antibody | B-lymphocyte antigen CD20 binding agent | 37 | 0 | 1,384 | CHEMBL1201576 |
| Enzalutamide | Small Molecule | Androgen Receptor antagonist | 35 | 20 | 299 | C71744 · CHEMBL1082407 |
| Filgrastim | Other | Granulocyte colony stimulating factor receptor agonist | 34 | 0 | 767 | CHEMBL1201567 |
| Trametinib | Small Molecule | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor; Dual specificity mitogen-activated protein kinase kinase 1 inhibitor; Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor | 33 | 162 | 224 | C77908 · CHEMBL2103875 |
| Dabrafenib | Small Molecule | Serine/threonine-protein kinase B-raf inhibitor | 32 | 107 | 123 | C82386 · CHEMBL2028663 |
| Nilotinib | Small Molecule | Tyrosine-protein kinase ABL inhibitor; Bcr/Abl fusion protein inhibitor | 31 | 66 | 134 | C48375 · CHEMBL255863 |
| Everolimus | Small Molecule | FK506-binding protein 1A inhibitor | 31 | 44 | 518 | C48387 · CHEMBL1908360 |
| Tamoxifen | Small Molecule | Estrogen receptor alpha modulator | 31 | 23 | 306 | C62078 · CHEMBL83 |
| Azacitidine | Small Molecule | DNA (cytosine-5)-methyltransferase 3A inhibitor; DNA (cytosine-5)-methyltransferase 1 inhibitor; DNA inhibitor; RNA inhibitor | 31 | 7 | 521 | C288 · CHEMBL1489 |
| Bendamustine | Small Molecule | DNA inhibitor | 31 | 0 | 282 | CHEMBL487253 |
| Ipilimumab | Monoclonal Antibody | Cytotoxic T-lymphocyte protein 4 inhibitor | 30 | 8 | 681 | C2654 · CHEMBL1789844 |
| Durvalumab | Monoclonal Antibody | Programmed cell death 1 ligand 1 inhibitor | 29 | 11 | 653 | C103194 · CHEMBL3301587 |
| Topotecan | Small Molecule | DNA topoisomerase I inhibitor | 29 | 1 | 372 | C1413 · CHEMBL84 |
| Irinotecan | Small Molecule | DNA topoisomerase I inhibitor | 28 | 44 | 963 | C62040 · CHEMBL481 |
| Bicalutamide | Small Molecule | Androgen Receptor antagonist | 28 | 4 | 138 | C1599 · CHEMBL409 |
| Pegfilgrastim | Other | Granulocyte colony stimulating factor receptor agonist | 27 | 0 | 223 | CHEMBL1201568 |
| Olaparib | Small Molecule | PARP 1, 2 and 3 inhibitor | 26 | 119 | 351 | C71721 · CHEMBL521686 |
| Imatinib Mesylate | Small Molecule | Tyrosine-protein kinase ABL inhibitor; Platelet-derived growth factor receptor beta inhibitor; Stem cell growth factor receptor inhibitor; Bcr/Abl fusion protein inhibitor | 26 | 100 | 188 | C1687 · CHEMBL1642 |
| Selpercatinib | Small Molecule | Tyrosine-protein kinase receptor RET inhibitor; Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitor; Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitor | 26 | 43 | 21 | C134987 · CHEMBL4559134 |
| Oxaliplatin | Small Molecule | DNA inhibitor | 26 | 22 | 1,219 | C1181 · CHEMBL414804 |
| Lenvatinib | Small Molecule | Vascular endothelial growth factor receptor inhibitor | 25 | 4 | 388 | C95124 · CHEMBL1289601 |
| Sertraline | Small Molecule | Serotonin transporter inhibitor | 24 | 1 | 6 | C61939 · CHEMBL809 |
| Erlotinib | Small Molecule | Epidermal growth factor receptor erbB1 inhibitor | 23 | 268 | 401 | C65530 · CHEMBL553 |
| Cytarabine | Small Molecule | DNA inhibitor; RNA inhibitor; DNA polymerase (alpha/delta/epsilon) inhibitor | 23 | 17 | 1,008 | C408 · CHEMBL803 |