Gene

KMT2B

lysine methyltransferase 2B

Explore in graph →CI-GENE-00007112HGNC:15840 ENSG00000272333 NCBI 9757 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KMT2A Mutation + KMT2B Mutation + KMT2C Mutation + KMT2D mutationKMT2C KMT2D KMT2A KMT2B2
Immune Checkpoint Inhibitor	Melanoma	Predictive	B	Supports Sensitivity Response	2	submitted	EID12592 In a retrospective pan-cancer analysis of four immune checkpoint therapy (ICT)–treated cohorts (melanoma n = 287; NSCLC n = 131; total n = 418), KMT2 family mutations were associated with improved ICT… (full text at CIViC) PMID 33653367 · Zhang et al., 2021 · Open in CIViC	civic
〃	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	2

Cohorts

Alteration frequency by cohort (150)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved150 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022	Endometrial Carcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.