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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
108 cases with simple somatic mutation data · 80 cases total · 2026-01-16 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 102 |
| 108 |
| 94.4% |
| cbioportal |
| 2 | TTN | Ssm | 74 | 108 | 68.5% | cbioportal |
| 3 | CSMD3 | Ssm | 51 | 108 | 47.2% | cbioportal |
| 4 | USH2A | Ssm | 43 | 108 | 39.8% | cbioportal |
| 6 | ZFHX4 | Ssm | 40 | 108 | 37% | cbioportal |
| 5 | RYR2 | Ssm | 40 | 108 | 37% | cbioportal |
| 8 | SYNE1 | Ssm | 34 | 108 | 31.5% | cbioportal |
| 7 | LRP1B | Ssm | 34 | 108 | 31.5% | cbioportal |
| 9 | FAM135B | Ssm | 33 | 108 | 30.6% | cbioportal |
| 10 | MUC16 | Ssm | 33 | 108 | 30.6% | cbioportal |
| 12 | KMT2D | Ssm | 26 | 108 | 24.1% | cbioportal |
| 11 | DNAH5 | Ssm | 26 | 108 | 24.1% | cbioportal |
| 13 | PCDH15 | Ssm | 25 | 108 | 23.1% | cbioportal |
| 14 | COL22A1 | Ssm | 23 | 108 | 21.3% | cbioportal |
| 16 | FSIP2 | Ssm | 22 | 108 | 20.4% | cbioportal |
| 15 | COL11A1 | Ssm | 22 | 108 | 20.4% | cbioportal |
| 18 | CDH10 | Ssm | 21 | 108 | 19.4% | cbioportal |
| 20 | OBSCN | Ssm | 21 | 108 | 19.4% | cbioportal |
| 22 | XIRP2 | Ssm | 21 | 108 | 19.4% | cbioportal |
| 19 | FAT3 | Ssm | 21 | 108 | 19.4% | cbioportal |
| 21 | RYR3 | Ssm | 21 | 108 | 19.4% | cbioportal |
| 17 | ADAMTS12 | Ssm | 21 | 108 | 19.4% | cbioportal |
| 28 | UNC80 | Ssm | 20 | 108 | 18.5% | cbioportal |
| 25 | FLG | Ssm | 20 | 108 | 18.5% | cbioportal |
| 24 | EYS | Ssm | 20 | 108 | 18.5% | cbioportal |
| 26 | NAV3 | Ssm | 20 | 108 | 18.5% | cbioportal |
| 27 | PCLO | Ssm | 20 | 108 | 18.5% | cbioportal |
| 23 | CSMD2 | Ssm | 20 | 108 | 18.5% | cbioportal |
| 35 | SI | Ssm | 19 | 108 | 17.6% | cbioportal |
| 29 | CUBN | Ssm | 19 | 108 | 17.6% | cbioportal |
Data updated 21 days agoSource updated 2026-01-16