Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
178 cases with simple somatic mutation data · 178 cases total · 2026-02-19 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 149 |
| 178 |
| 83.7% |
| cbioportal |
| 2 | TTN | Ssm | 129 | 178 | 72.5% | cbioportal |
| 3 | CSMD3 | Ssm | 80 | 178 | 44.9% | cbioportal |
| 4 | RYR2 | Ssm | 78 | 178 | 43.8% | cbioportal |
| 5 | MUC16 | Ssm | 74 | 178 | 41.6% | cbioportal |
| 7 | ZFHX4 | Ssm | 68 | 178 | 38.2% | cbioportal |
| 6 | LRP1B | Ssm | 68 | 178 | 38.2% | cbioportal |
| 8 | USH2A | Ssm | 67 | 178 | 37.6% | cbioportal |
| 9 | SYNE1 | Ssm | 52 | 178 | 29.2% | cbioportal |
| 10 | RYR3 | Ssm | 49 | 178 | 27.5% | cbioportal |
| 11 | DNAH11 | Ssm | 40 | 178 | 22.5% | cbioportal |
| 12 | FLG | Ssm | 40 | 178 | 22.5% | cbioportal |
| 13 | FAM135B | Ssm | 39 | 178 | 21.9% | cbioportal |
| 15 | SPTA1 | Ssm | 39 | 178 | 21.9% | cbioportal |
| 14 | PKHD1 | Ssm | 39 | 178 | 21.9% | cbioportal |
| 16 | PKHD1L1 | Ssm | 38 | 178 | 21.3% | cbioportal |
| 18 | SI | Ssm | 37 | 178 | 20.8% | cbioportal |
| 17 | KMT2D | Ssm | 37 | 178 | 20.8% | cbioportal |
| 19 | COL11A1 | Ssm | 36 | 178 | 20.2% | cbioportal |
| 20 | NAV3 | Ssm | 36 | 178 | 20.2% | cbioportal |
| 21 | LRP2 | Ssm | 35 | 178 | 19.7% | cbioportal |
| 22 | XIRP2 | Ssm | 35 | 178 | 19.7% | cbioportal |
| 23 | ERICH3 | Ssm | 34 | 178 | 19.1% | cbioportal |
| 24 | HCN1 | Ssm | 34 | 178 | 19.1% | cbioportal |
| 25 | MUC17 | Ssm | 34 | 178 | 19.1% | cbioportal |
| 29 | CUBN | Ssm | 33 | 178 | 18.5% | cbioportal |
| 32 | ZNF536 | Ssm | 33 | 178 | 18.5% | cbioportal |
| 27 | CDH10 | Ssm | 33 | 178 | 18.5% | cbioportal |
| 30 | DNAH5 | Ssm | 33 | 178 | 18.5% | cbioportal |
| 26 | AHNAK2 | Ssm | 33 | 178 | 18.5% | cbioportal |
Data updated 21 days agoSource updated 2026-02-19