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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
368 cases with simple somatic mutation data · 480 cases total · 2026-01-13 · mapped to Cutaneous Melanoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TTN | Ssm | 265 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 368 |
| 72% |
| cbioportal |
| 2 | MUC16 | Ssm | 250 | 368 | 67.9% | cbioportal |
| 3 | BRAF | Ssm | 189 | 368 | 51.4% | cbioportal |
| 4 | DNAH5 | Ssm | 179 | 368 | 48.6% | cbioportal |
| 5 | PCLO | Ssm | 160 | 368 | 43.5% | cbioportal |
| 6 | LRP1B | Ssm | 138 | 368 | 37.5% | cbioportal |
| 7 | CSMD1 | Ssm | 130 | 368 | 35.3% | cbioportal |
| 8 | ADGRV1 | Ssm | 127 | 368 | 34.5% | cbioportal |
| 10 | RP1 | Ssm | 123 | 368 | 33.4% | cbioportal |
| 9 | MGAM | Ssm | 123 | 368 | 33.4% | cbioportal |
| 11 | DNAH7 | Ssm | 122 | 368 | 33.2% | cbioportal |
| 12 | ANK3 | Ssm | 118 | 368 | 32.1% | cbioportal |
| 13 | XIRP2 | Ssm | 116 | 368 | 31.5% | cbioportal |
| 14 | DSCAM | Ssm | 115 | 368 | 31.3% | cbioportal |
| 15 | APOB | Ssm | 114 | 368 | 31% | cbioportal |
| 16 | CSMD2 | Ssm | 113 | 368 | 30.7% | cbioportal |
| 17 | CSMD3 | Ssm | 113 | 368 | 30.7% | cbioportal |
| 18 | FLG | Ssm | 113 | 368 | 30.7% | cbioportal |
| 19 | MUC17 | Ssm | 112 | 368 | 30.4% | cbioportal |
| 20 | PKHD1L1 | Ssm | 112 | 368 | 30.4% | cbioportal |
| 21 | DNAH9 | Ssm | 111 | 368 | 30.2% | cbioportal |
| 22 | USH2A | Ssm | 110 | 368 | 29.9% | cbioportal |
| 23 | FAT4 | Ssm | 109 | 368 | 29.6% | cbioportal |
| 24 | THSD7B | Ssm | 108 | 368 | 29.3% | cbioportal |
| 25 | FAT3 | Ssm | 107 | 368 | 29.1% | cbioportal |
| 26 | DNAH8 | Ssm | 106 | 368 | 28.8% | cbioportal |
| 27 | DNAH3 | Ssm | 104 | 368 | 28.3% | cbioportal |
| 28 | MXRA5 | Ssm | 102 | 368 | 27.7% | cbioportal |
| 29 | PTPRT | Ssm | 102 | 368 | 27.7% | cbioportal |
| 30 | NRAS | Ssm | 98 | 368 | 26.6% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13