Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
510 cases with simple somatic mutation data · 530 cases total · 2026-01-13 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 357 |
| 510 |
| 70% |
| cbioportal |
| 2 | TTN | Ssm | 188 | 510 | 36.9% | cbioportal |
| 3 | FAT1 | Ssm | 108 | 510 | 21.2% | cbioportal |
| 4 | CDKN2A | Ssm | 103 | 510 | 20.2% | cbioportal |
| 5 | CSMD3 | Ssm | 91 | 510 | 17.8% | cbioportal |
| 6 | MUC16 | Ssm | 90 | 510 | 17.6% | cbioportal |
| 7 | NOTCH1 | Ssm | 89 | 510 | 17.5% | cbioportal |
| 8 | PIK3CA | Ssm | 85 | 510 | 16.7% | cbioportal |
| 9 | SYNE1 | Ssm | 83 | 510 | 16.3% | cbioportal |
| 10 | LRP1B | Ssm | 79 | 510 | 15.5% | cbioportal |
| 11 | KMT2D | Ssm | 70 | 510 | 13.7% | cbioportal |
| 12 | PCLO | Ssm | 70 | 510 | 13.7% | cbioportal |
| 13 | DNAH5 | Ssm | 65 | 510 | 12.7% | cbioportal |
| 15 | USH2A | Ssm | 58 | 510 | 11.4% | cbioportal |
| 14 | FLG | Ssm | 58 | 510 | 11.4% | cbioportal |
| 16 | NSD1 | Ssm | 56 | 510 | 11% | cbioportal |
| 17 | CASP8 | Ssm | 53 | 510 | 10.4% | cbioportal |
| 18 | RYR2 | Ssm | 50 | 510 | 9.8% | cbioportal |
| 19 | XIRP2 | Ssm | 48 | 510 | 9.4% | cbioportal |
| 20 | FAM135B | Ssm | 47 | 510 | 9.2% | cbioportal |
| 21 | PKHD1L1 | Ssm | 47 | 510 | 9.2% | cbioportal |
| 22 | AHNAK | Ssm | 46 | 510 | 9% | cbioportal |
| 23 | DMD | Ssm | 45 | 510 | 8.8% | cbioportal |
| 24 | DST | Ssm | 45 | 510 | 8.8% | cbioportal |
| 25 | HUWE1 | Ssm | 45 | 510 | 8.8% | cbioportal |
| 26 | SI | Ssm | 44 | 510 | 8.6% | cbioportal |
| 28 | RELN | Ssm | 43 | 510 | 8.4% | cbioportal |
| 27 | PAPPA2 | Ssm | 43 | 510 | 8.4% | cbioportal |
| 29 | FAT3 | Ssm | 42 | 510 | 8.2% | cbioportal |
| 30 | COL11A1 | Ssm | 41 | 510 | 8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13