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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
158 cases with simple somatic mutation data · 263 cases total · 2026-02-11 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | VHL |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 106 |
| 158 |
| 67.1% |
| cbioportal |
| 2 | PBRM1 | Ssm | 79 | 158 | 50% | cbioportal |
| 3 | TTN | Ssm | 67 | 158 | 42.4% | cbioportal |
| 4 | MUC16 | Ssm | 60 | 158 | 38% | cbioportal |
| 5 | AHNAK2 | Ssm | 56 | 158 | 35.4% | cbioportal |
| 6 | SETD2 | Ssm | 52 | 158 | 32.9% | cbioportal |
| 7 | OBSCN | Ssm | 51 | 158 | 32.3% | cbioportal |
| 8 | HSPG2 | Ssm | 48 | 158 | 30.4% | cbioportal |
| 9 | KMT2D | Ssm | 46 | 158 | 29.1% | cbioportal |
| 10 | LRP1 | Ssm | 45 | 158 | 28.5% | cbioportal |
| 11 | BSN | Ssm | 44 | 158 | 27.8% | cbioportal |
| 12 | MUC5B | Ssm | 44 | 158 | 27.8% | cbioportal |
| 13 | ZNF469 | Ssm | 41 | 158 | 25.9% | cbioportal |
| 14 | ZNF594 | Ssm | 40 | 158 | 25.3% | cbioportal |
| 15 | COL7A1 | Ssm | 39 | 158 | 24.7% | cbioportal |
| 16 | LAMA5 | Ssm | 39 | 158 | 24.7% | cbioportal |
| 20 | OTOG | Ssm | 38 | 158 | 24.1% | cbioportal |
| 18 | FLNA | Ssm | 38 | 158 | 24.1% | cbioportal |
| 19 | MUC5AC | Ssm | 38 | 158 | 24.1% | cbioportal |
| 21 | PLEC | Ssm | 38 | 158 | 24.1% | cbioportal |
| 17 | AHNAK | Ssm | 38 | 158 | 24.1% | cbioportal |
| 24 | SYNE1 | Ssm | 37 | 158 | 23.4% | cbioportal |
| 23 | RYR1 | Ssm | 37 | 158 | 23.4% | cbioportal |
| 22 | DNAH1 | Ssm | 37 | 158 | 23.4% | cbioportal |
| 27 | PLXNB3 | Ssm | 36 | 158 | 22.8% | cbioportal |
| 26 | KIF1A | Ssm | 36 | 158 | 22.8% | cbioportal |
| 25 | IRF2BPL | Ssm | 36 | 158 | 22.8% | cbioportal |
| 28 | SPEG | Ssm | 35 | 158 | 22.2% | cbioportal |
| 37 | USP7 | Ssm | 34 | 158 | 21.5% | cbioportal |
| 30 | CACNA1H | Ssm | 34 | 158 | 21.5% | cbioportal |
Data updated 21 days agoSource updated 2026-02-11