Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
534 cases with simple somatic mutation data · 594 cases total · 2026-06-05 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 1 | APC | Ssm | 387 | 534 | 72.5% | cbioportal |
| 2 | TP53 | Ssm | 314 | 534 | 58.8% | cbioportal |
| 3 | TTN | Ssm | 257 | 534 | 48.1% | cbioportal |
| 4 | KRAS | Ssm | 218 | 534 | 40.8% | cbioportal |
| 5 | PIK3CA | Ssm | 147 | 534 | 27.5% | cbioportal |
| 6 | MUC16 | Ssm | 146 | 534 | 27.3% | cbioportal |
| 7 | SYNE1 | Ssm | 144 | 534 | 27% | cbioportal |
| 8 | FAT4 | Ssm | 124 | 534 | 23.2% | cbioportal |
| 9 | RYR2 | Ssm | 105 | 534 | 19.7% | cbioportal |
| 10 | OBSCN | Ssm | 99 | 534 | 18.5% | cbioportal |
| 11 | ZFHX4 | Ssm | 95 | 534 | 17.8% | cbioportal |
| 12 | FLG | Ssm | 94 | 534 | 17.6% | cbioportal |
| 13 | LRP1B | Ssm | 94 | 534 | 17.6% | cbioportal |
| 15 | DNAH5 | Ssm | 92 | 534 | 17.2% | cbioportal |
| 14 | CSMD1 | Ssm | 92 | 534 | 17.2% | cbioportal |
| 16 | FBXW7 | Ssm | 90 | 534 | 16.9% | cbioportal |
| 17 | CSMD3 | Ssm | 89 | 534 | 16.7% | cbioportal |
| 18 | DNAH11 | Ssm | 85 | 534 | 15.9% | cbioportal |
| 19 | RYR1 | Ssm | 83 | 534 | 15.5% | cbioportal |
| 20 | FAT3 | Ssm | 81 | 534 | 15.2% | cbioportal |
| 21 | PCLO | Ssm | 80 | 534 | 15% | cbioportal |
| 22 | USH2A | Ssm | 79 | 534 | 14.8% | cbioportal |
| 23 | ABCA13 | Ssm | 77 | 534 | 14.4% | cbioportal |
| 24 | RYR3 | Ssm | 77 | 534 | 14.4% | cbioportal |
| 25 | HYDIN | Ssm | 76 | 534 | 14.2% | cbioportal |
| 26 | NEB | Ssm | 74 | 534 | 13.9% | cbioportal |
| 28 | DMD | Ssm | 72 | 534 | 13.5% | cbioportal |
| 27 | ADGRV1 | Ssm | 72 | 534 | 13.5% | cbioportal |
| 30 | LRP2 | Ssm | 70 | 534 | 13.1% | cbioportal |
| 29 | ATM | Ssm | 70 | 534 | 13.1% | cbioportal |
Data updated 21 days agoSource updated 2026-06-05