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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
484 cases with simple somatic mutation data · 503 cases total · 2026-01-13 · mapped to Lung Squamous Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 408 |
| 484 |
| 84.3% |
| cbioportal |
| 2 | TTN | Ssm | 340 | 484 | 70.2% | cbioportal |
| 3 | CSMD3 | Ssm | 205 | 484 | 42.4% | cbioportal |
| 4 | MUC16 | Ssm | 187 | 484 | 38.6% | cbioportal |
| 5 | RYR2 | Ssm | 179 | 484 | 37% | cbioportal |
| 6 | LRP1B | Ssm | 160 | 484 | 33.1% | cbioportal |
| 7 | USH2A | Ssm | 156 | 484 | 32.2% | cbioportal |
| 8 | SYNE1 | Ssm | 148 | 484 | 30.6% | cbioportal |
| 9 | ZFHX4 | Ssm | 142 | 484 | 29.3% | cbioportal |
| 10 | FAM135B | Ssm | 112 | 484 | 23.1% | cbioportal |
| 11 | KMT2D | Ssm | 105 | 484 | 21.7% | cbioportal |
| 12 | NAV3 | Ssm | 101 | 484 | 20.9% | cbioportal |
| 13 | XIRP2 | Ssm | 95 | 484 | 19.6% | cbioportal |
| 14 | CDH10 | Ssm | 93 | 484 | 19.2% | cbioportal |
| 15 | RYR3 | Ssm | 93 | 484 | 19.2% | cbioportal |
| 16 | SPTA1 | Ssm | 93 | 484 | 19.2% | cbioportal |
| 17 | PKHD1 | Ssm | 90 | 484 | 18.6% | cbioportal |
| 18 | PCDH15 | Ssm | 89 | 484 | 18.4% | cbioportal |
| 19 | PCLO | Ssm | 87 | 484 | 18% | cbioportal |
| 20 | PAPPA2 | Ssm | 86 | 484 | 17.8% | cbioportal |
| 22 | DNAH8 | Ssm | 84 | 484 | 17.4% | cbioportal |
| 21 | DNAH5 | Ssm | 84 | 484 | 17.4% | cbioportal |
| 23 | PKHD1L1 | Ssm | 83 | 484 | 17.1% | cbioportal |
| 24 | MUC17 | Ssm | 80 | 484 | 16.5% | cbioportal |
| 25 | FLG | Ssm | 79 | 484 | 16.3% | cbioportal |
| 26 | ADAMTS12 | Ssm | 78 | 484 | 16.1% | cbioportal |
| 27 | HCN1 | Ssm | 78 | 484 | 16.1% | cbioportal |
| 29 | SI | Ssm | 77 | 484 | 15.9% | cbioportal |
| 28 | ERICH3 | Ssm | 77 | 484 | 15.9% | cbioportal |
| 31 | COL22A1 | Ssm | 76 | 484 | 15.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13