Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
397 cases with simple somatic mutation data · 592 cases total · 2026-06-05 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| PTEN |
| Ssm |
| 133 |
| 397 |
| 33.5% |
| cbioportal |
| 2 | TP53 | Ssm | 125 | 397 | 31.5% | cbioportal |
| 3 | TTN | Ssm | 101 | 397 | 25.4% | cbioportal |
| 4 | EGFR | Ssm | 94 | 397 | 23.7% | cbioportal |
| 5 | MUC16 | Ssm | 61 | 397 | 15.4% | cbioportal |
| 6 | FLG | Ssm | 53 | 397 | 13.4% | cbioportal |
| 7 | NF1 | Ssm | 46 | 397 | 11.6% | cbioportal |
| 8 | RYR2 | Ssm | 43 | 397 | 10.8% | cbioportal |
| 9 | PIK3R1 | Ssm | 39 | 397 | 9.8% | cbioportal |
| 10 | PIK3CA | Ssm | 38 | 397 | 9.6% | cbioportal |
| 11 | RB1 | Ssm | 38 | 397 | 9.6% | cbioportal |
| 12 | SPTA1 | Ssm | 38 | 397 | 9.6% | cbioportal |
| 13 | ATRX | Ssm | 37 | 397 | 9.3% | cbioportal |
| 14 | SYNE1 | Ssm | 34 | 397 | 8.6% | cbioportal |
| 15 | LRP2 | Ssm | 29 | 397 | 7.3% | cbioportal |
| 16 | MUC17 | Ssm | 29 | 397 | 7.3% | cbioportal |
| 17 | PCLO | Ssm | 28 | 397 | 7.1% | cbioportal |
| 19 | PKHD1 | Ssm | 27 | 397 | 6.8% | cbioportal |
| 18 | HMCN1 | Ssm | 27 | 397 | 6.8% | cbioportal |
| 21 | OBSCN | Ssm | 26 | 397 | 6.5% | cbioportal |
| 20 | COL6A3 | Ssm | 26 | 397 | 6.5% | cbioportal |
| 22 | AHNAK2 | Ssm | 25 | 397 | 6.3% | cbioportal |
| 23 | IDH1 | Ssm | 25 | 397 | 6.3% | cbioportal |
| 25 | DNAH5 | Ssm | 24 | 397 | 6% | cbioportal |
| 24 | DNAH2 | Ssm | 24 | 397 | 6% | cbioportal |
| 27 | FLG2 | Ssm | 22 | 397 | 5.5% | cbioportal |
| 28 | USH2A | Ssm | 22 | 397 | 5.5% | cbioportal |
| 26 | FAT2 | Ssm | 22 | 397 | 5.5% | cbioportal |
| 31 | HRNR | Ssm | 21 | 397 | 5.3% | cbioportal |
| 30 | CFAP47 | Ssm | 21 | 397 | 5.3% | cbioportal |
Data updated 21 days agoSource updated 2026-06-05