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CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
352 cases with simple somatic mutation data · 354 cases total · 2026-01-14 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | VHL | Ssm | 237 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 352 |
| 67.3% |
| cbioportal |
| 2 | PBRM1 | Ssm | 114 | 352 | 32.4% | cbioportal |
| 3 | BAP1 | Ssm | 48 | 352 | 13.6% | cbioportal |
| 4 | TTN | Ssm | 44 | 352 | 12.5% | cbioportal |
| 5 | KDM5C | Ssm | 43 | 352 | 12.2% | cbioportal |
| 6 | SETD2 | Ssm | 39 | 352 | 11.1% | cbioportal |
| 7 | CSMD3 | Ssm | 34 | 352 | 9.7% | cbioportal |
| 8 | MTOR | Ssm | 23 | 352 | 6.5% | cbioportal |
| 9 | LRP2 | Ssm | 20 | 352 | 5.7% | cbioportal |
| 10 | MUC16 | Ssm | 20 | 352 | 5.7% | cbioportal |
| 12 | USH2A | Ssm | 19 | 352 | 5.4% | cbioportal |
| 11 | RYR2 | Ssm | 19 | 352 | 5.4% | cbioportal |
| 13 | CUBN | Ssm | 18 | 352 | 5.1% | cbioportal |
| 14 | MUC17 | Ssm | 17 | 352 | 4.8% | cbioportal |
| 15 | YLPM1 | Ssm | 17 | 352 | 4.8% | cbioportal |
| 19 | ZNF292 | Ssm | 16 | 352 | 4.5% | cbioportal |
| 17 | SYNE1 | Ssm | 16 | 352 | 4.5% | cbioportal |
| 16 | HMCN1 | Ssm | 16 | 352 | 4.5% | cbioportal |
| 18 | SYNE2 | Ssm | 16 | 352 | 4.5% | cbioportal |
| 23 | SI | Ssm | 15 | 352 | 4.3% | cbioportal |
| 21 | FSIP2 | Ssm | 15 | 352 | 4.3% | cbioportal |
| 22 | MACF1 | Ssm | 15 | 352 | 4.3% | cbioportal |
| 20 | DST | Ssm | 15 | 352 | 4.3% | cbioportal |
| 26 | DNAH5 | Ssm | 14 | 352 | 4% | cbioportal |
| 24 | APOB | Ssm | 14 | 352 | 4% | cbioportal |
| 25 | BIRC6 | Ssm | 14 | 352 | 4% | cbioportal |
| 27 | PKD1 | Ssm | 14 | 352 | 4% | cbioportal |
| 31 | USP34 | Ssm | 13 | 352 | 3.7% | cbioportal |
| 28 | GOLGB1 | Ssm | 13 | 352 | 3.7% | cbioportal |
| 32 | ZNF91 | Ssm | 13 | 352 | 3.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-14