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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
104 cases with simple somatic mutation data · 109 cases total · 2026-01-14 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | APC | Ssm | 79 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 104 |
| 76% |
| cbioportal |
| 2 | TP53 | Ssm | 57 | 104 | 54.8% | cbioportal |
| 3 | TTN | Ssm | 50 | 104 | 48.1% | cbioportal |
| 4 | KRAS | Ssm | 36 | 104 | 34.6% | cbioportal |
| 5 | MUC16 | Ssm | 28 | 104 | 26.9% | cbioportal |
| 6 | SYNE1 | Ssm | 27 | 104 | 26% | cbioportal |
| 7 | CSMD3 | Ssm | 25 | 104 | 24% | cbioportal |
| 8 | FAT3 | Ssm | 25 | 104 | 24% | cbioportal |
| 9 | RYR1 | Ssm | 24 | 104 | 23.1% | cbioportal |
| 10 | FAT4 | Ssm | 23 | 104 | 22.1% | cbioportal |
| 11 | HMCN1 | Ssm | 23 | 104 | 22.1% | cbioportal |
| 13 | PIK3CA | Ssm | 22 | 104 | 21.2% | cbioportal |
| 14 | ZNF469 | Ssm | 22 | 104 | 21.2% | cbioportal |
| 12 | OBSCN | Ssm | 22 | 104 | 21.2% | cbioportal |
| 16 | DNAH5 | Ssm | 21 | 104 | 20.2% | cbioportal |
| 17 | LRTM3 | Ssm | 21 | 104 | 20.2% | cbioportal |
| 15 | ACVR2A | Ssm | 21 | 104 | 20.2% | cbioportal |
| 19 | SOX9 | Ssm | 20 | 104 | 19.2% | cbioportal |
| 20 | SPEG | Ssm | 20 | 104 | 19.2% | cbioportal |
| 18 | COL5A1 | Ssm | 20 | 104 | 19.2% | cbioportal |
| 22 | DMD | Ssm | 19 | 104 | 18.3% | cbioportal |
| 21 | ARID1A | Ssm | 19 | 104 | 18.3% | cbioportal |
| 24 | NBEA | Ssm | 19 | 104 | 18.3% | cbioportal |
| 23 | MYCBP2 | Ssm | 19 | 104 | 18.3% | cbioportal |
| 25 | RYR2 | Ssm | 19 | 104 | 18.3% | cbioportal |
| 29 | PCLO | Ssm | 18 | 104 | 17.3% | cbioportal |
| 26 | ADGRV1 | Ssm | 18 | 104 | 17.3% | cbioportal |
| 32 | ZFHX4 | Ssm | 18 | 104 | 17.3% | cbioportal |
| 30 | PLEC | Ssm | 18 | 104 | 17.3% | cbioportal |
| 31 | TRPS1 | Ssm | 18 | 104 | 17.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-14