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CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
1,144 cases with simple somatic mutation data · 1,144 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 775 |
| 1,144 |
| 67.7% |
| cbioportal |
| 2 | TTN | Ssm | 682 | 1,144 | 59.6% | cbioportal |
| 3 | CSMD3 | Ssm | 477 | 1,144 | 41.7% | cbioportal |
| 4 | MUC16 | Ssm | 463 | 1,144 | 40.5% | cbioportal |
| 5 | RYR2 | Ssm | 448 | 1,144 | 39.2% | cbioportal |
| 6 | LRP1B | Ssm | 402 | 1,144 | 35.1% | cbioportal |
| 7 | USH2A | Ssm | 390 | 1,144 | 34.1% | cbioportal |
| 8 | ZFHX4 | Ssm | 356 | 1,144 | 31.1% | cbioportal |
| 9 | SPTA1 | Ssm | 284 | 1,144 | 24.8% | cbioportal |
| 10 | XIRP2 | Ssm | 268 | 1,144 | 23.4% | cbioportal |
| 12 | SYNE1 | Ssm | 253 | 1,144 | 22.1% | cbioportal |
| 11 | FLG | Ssm | 253 | 1,144 | 22.1% | cbioportal |
| 13 | NAV3 | Ssm | 234 | 1,144 | 20.5% | cbioportal |
| 14 | PCDH15 | Ssm | 230 | 1,144 | 20.1% | cbioportal |
| 15 | CSMD1 | Ssm | 225 | 1,144 | 19.7% | cbioportal |
| 16 | FAM135B | Ssm | 223 | 1,144 | 19.5% | cbioportal |
| 18 | KRAS | Ssm | 222 | 1,144 | 19.4% | cbioportal |
| 17 | FAT3 | Ssm | 222 | 1,144 | 19.4% | cbioportal |
| 19 | MUC17 | Ssm | 219 | 1,144 | 19.1% | cbioportal |
| 20 | PCLO | Ssm | 219 | 1,144 | 19.1% | cbioportal |
| 21 | RYR3 | Ssm | 217 | 1,144 | 19% | cbioportal |
| 22 | COL11A1 | Ssm | 214 | 1,144 | 18.7% | cbioportal |
| 23 | PAPPA2 | Ssm | 212 | 1,144 | 18.5% | cbioportal |
| 24 | APOB | Ssm | 210 | 1,144 | 18.4% | cbioportal |
| 25 | SI | Ssm | 203 | 1,144 | 17.7% | cbioportal |
| 26 | CDH10 | Ssm | 202 | 1,144 | 17.7% | cbioportal |
| 27 | DNAH9 | Ssm | 197 | 1,144 | 17.2% | cbioportal |
| 28 | ADAMTS12 | Ssm | 196 | 1,144 | 17.1% | cbioportal |
| 29 | ZNF536 | Ssm | 195 | 1,144 | 17% | cbioportal |
| 30 | TNR | Ssm | 192 | 1,144 | 16.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-12