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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
426 cases with simple somatic mutation data · 426 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 155 |
| 426 |
| 36.4% |
| cbioportal |
| 2 | KRAS | Ssm | 147 | 426 | 34.5% | cbioportal |
| 3 | EGFR | Ssm | 139 | 426 | 32.6% | cbioportal |
| 4 | RBM10 | Ssm | 81 | 426 | 19% | cbioportal |
| 5 | STK11 | Ssm | 66 | 426 | 15.5% | cbioportal |
| 6 | KEAP1 | Ssm | 46 | 426 | 10.8% | cbioportal |
| 7 | FAT1 | Ssm | 36 | 426 | 8.5% | cbioportal |
| 8 | NF1 | Ssm | 35 | 426 | 8.2% | cbioportal |
| 10 | SETD2 | Ssm | 34 | 426 | 8% | cbioportal |
| 9 | PTPRD | Ssm | 34 | 426 | 8% | cbioportal |
| 11 | PTPRT | Ssm | 32 | 426 | 7.5% | cbioportal |
| 12 | ATM | Ssm | 30 | 426 | 7% | cbioportal |
| 13 | BRAF | Ssm | 29 | 426 | 6.8% | cbioportal |
| 14 | SMARCA4 | Ssm | 29 | 426 | 6.8% | cbioportal |
| 16 | MED12 | Ssm | 28 | 426 | 6.6% | cbioportal |
| 15 | KMT2D | Ssm | 28 | 426 | 6.6% | cbioportal |
| 21 | MGA | Ssm | 24 | 418 | 5.7% | cbioportal |
| 19 | KMT2C | Ssm | 24 | 426 | 5.6% | cbioportal |
| 20 | MET | Ssm | 24 | 426 | 5.6% | cbioportal |
| 17 | EPHA3 | Ssm | 24 | 426 | 5.6% | cbioportal |
| 22 | NTRK3 | Ssm | 24 | 426 | 5.6% | cbioportal |
| 18 | GRIN2A | Ssm | 24 | 426 | 5.6% | cbioportal |
| 23 | ARID2 | Ssm | 23 | 426 | 5.4% | cbioportal |
| 27 | PIK3CA | Ssm | 22 | 426 | 5.2% | cbioportal |
| 26 | PIK3C2G | Ssm | 22 | 426 | 5.2% | cbioportal |
| 24 | EPHA5 | Ssm | 22 | 426 | 5.2% | cbioportal |
| 25 | ERBB4 | Ssm | 22 | 426 | 5.2% | cbioportal |
| 28 | FLT1 | Ssm | 21 | 426 | 4.9% | cbioportal |
| 29 | NOTCH4 | Ssm | 21 | 426 | 4.9% | cbioportal |
| 30 | TERT | Ssm | 20 | 426 | 4.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07